Results 91 to 100 of about 575,364 (288)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Turning on by turning

The Journal of Cell Biology, 2005
Growth hormone activates its dimeric receptor (the growth hormone receptor [GHR]) by rotating one subunit relative to the other, according to Richard Brown, Michael Waters (University of Queensland, Australia), and colleagues. Figure Receptor rotation aligns activating kinases.
openaire   +2 more sources

The Influence of Solid Lubricant On Machining Quality in Turning of S45C Mild Steel

, 2013
Conference Venue : UniKL MFIProduct quality is one of the crucial criteria for the evaluation of turning process. However, heat generated in the cutting zone during machining might deteriorates the surface quality especially because of the tool wear ...
Izatul Hamimi Abdul Razak, Nor Khamsi Ahmad, Siti Hartini Hamdan, Mastura Samsudin, Mohd Shahril Mohd Yusop   +2 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Influence of Tool-Workpiece Interface on Surface Integrity after Turning

Communications, 2014
This paper deals with influence of flank wear on decomposition of cutting force in turning roll bearing steel. The decomposition is carried out to evaluate the components of cutting force in the tool-chip as well as tool-workpiece interface.
Jaroslav Dubec, Miroslav Neslusan, Anna Micietova, Maria Cillikova   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Investigations of Surface Roughness and Temperatures in Vegetable Oil-based n-MQL Turning of AISI 4340 Steel [PDF]

Journal of Engineering, Project, and Production Management
Machining of hard materials has been difficult and expensive because of poor surface smoothness, early tool failures, etc. When used in machining hard materials, such as medium and high carbon, cast steels, Inconel, and other alloys, nanomaterials ...
VeeraBhadraRao Miriyala, Bhushan T. Patil, Vasim A. Shaikh, D.S.S. Sudhakar, Sujata Deshmukh   +4 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Natural dye modification of polyethylene oxide: optical characterization and dielectric enhancement

Journal of Materials Science: Materials in Engineering
This study explores the optical properties of polyethylene oxide (PEO) modified with natural dye extracted from hollyhock (HH) flowers. This study is a green chemistry approach to reduce the optical band gap of PEO polymer.
Shujahadeen B. Aziz, Dana S. Muhammad, Sewara J. Mohammed, Daron Q. Muheddin, Shakhawan Al-Zangana, Ahang M. Hussein, Ary R. Murad, Govar H. Hamasalih, Samir M. Hamad, Dilshad Shaikhah   +9 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source