Results 41 to 50 of about 430,172 (298)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A Comparative Thermal Analysis of Two Workpiece Materials of Different Machinability When Turning Based on Ir Thermography

Journal of Machine Engineering
The comparative thermography analysis of temperature during machining by turning was presented. For the tests cast iron EN-GJL 250 and stainless steel 1.4301 were used. The machining by turning was performed with the TNMG 220408HS PC9030 and TNMA 220208
Andrzej Uhryński, Saltanat Nurkusheva, Muratbek Usserbayev, Paweł Hyla, Michał Bembenek   +4 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Integrated source reduction and treatment of metalworking fluid wastewater through induction-assisted dry hard turning of hardened SKD61 Steel

Desalination and Water Treatment
Metalworking-fluid wastewater from hard turning contains oil, suspended solids, metallic fines, and persistent organic pollutants, creating an environmental challenge for machining workshops.
Hoang Anh Tuan, Nguyen Ngoc Anh, Trieu Quy Huy   +2 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Modelling of cutting fibrous composite materials: current practice [PDF]

, 2015
Using fibre reinforced polymers (FRP) is increasing across many industries. Although FRP are laid-up in the near-net shape, several cutting operations are necessary to meet quality and dimensional requirements.
Kahwash, Fadi, Maheri, A., Shyha, Islam, Kahwash, F., Shyha, I., Maheri, Alireza   +5 more
core   +1 more source

Presentation of a novel "Simultaneous Three Axis Turning" process for time and cost efficient machining of rotational symmetric turbomachinery components

, 2022
In this paper a turning process is presented which is enhanced by a third tool movement axis. Besides the two already existing translational X- and Z-axes an additional rotational axis is added to the process.
Klocke, Fritz, Bergs, Thomas, Degen, Florian   +2 more
core   +2 more sources

Experimental Investigation on the Advantages of Dry Machining over Wet Machining during Turning of AISI 1020 Steel [PDF]

, 2021
In this study, the experiment was conducted to investigate the advantage of dry machining over wet machining during turning of AISI 1020 steel using cemented carbide tool on a CNC lathe machine.
Woyesssa, Guteta Kabeta, Bedada, Boki Dugo, Gemechu, Tekle, Jiru, Moera Gutu, Fetene, Besufekad Negash, Tekle Gemechu, Guteta Kabeta Woyesssa, Moera Gutu Jiru, Boki Dugo Bedada, Besufekad Negash Fetene   +9 more
core   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source