Results 61 to 70 of about 430,172 (298)

Laser-assisted machining of Inconel 718 with carbide and ceramic inserts [PDF]

, 2008
Laser assisted machining (LAM) can improve the machinability of materials by locally heating the material prior to its removal. The work presented here is a study of the laser assisted machining of Inconel 718 (NiCr19FeNb at 46 HRc) with carbide and ...
GERMAIN, Guénaël, AUGER, Stéphane, LEBRUN, Jean-Lou, BELLETT, Daniel, Bouchnak Braham, Tarek, BRAHAM-BOUCHNAK, Tarek   +5 more
core   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Experimental study of coated carbide tools behaviour: application for Ti-5-5-5-3 turning [PDF]

, 2011
The goal of this paper is to study the relation between the input data (conditions and geometry of cut) and answers (wear of tool, forces and cutting temperatures) when machining the Ti-5-5-5-3 alloy treated. This study has shown that the cutting process
Wagner, Vincent, V. Wagner, Baili, Maher, Lallement, Daniel, M. Baili, G. Dessein, Dessein, Gilles, D. Lallement   +7 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Modelling of cutting block cut surface at faceted surfaces machining using planetary gear set

MATEC Web of Conferences, 2017
The article resolved the relevant problem to assign process parameters for polygonal turning machining ensuring the component has its pre-set characteristics.
Kuts Vadim, Razumov Mikhail, Kalutskikh Nikolay   +2 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Evaluation of Laser Structuring in Hard Turning Process of Martensitic Steel

Journal of Manufacturing and Materials Processing
The hard turning process presents significant challenges compared to conventional turning techniques, particularly in terms of controlling machining forces and dimensional accuracy. This study evaluates the effectiveness of laser structuring in enhancing
Esmaeil Ghadiri Zahrani, Amir Alinaghizadeh, Amirmohammad Fakharzadeh Jahromi, Bahman Azarhoushang   +3 more
doaj   +1 more source

Micro turning with closed electrolytic free jet

, 2011
S.97-103The Electrochemical Machining (ECM) with a closed electrolytic free jet (Jet-ECM) is an innovative micro manufacturing technology. Based on anodic dissolution micro structured surfaces and complex three-dimensional geometries can be machined.
Meichsner, G., Zinecker, M., Hackert, M., Schubert, A.   +3 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source