Results 61 to 70 of about 193,633 (262)

Characteristics of non‐fatal opioid overdoses attended by ambulance services in Australia

Australian and New Zealand Journal of Public Health, 2004
Objective: To examine the feasibility of establishing a database on non‐fatal opioid overdose in order to examine patterns and characteristics of these overdoses across Australia.
Paul Dietze, Damien Jolley, Stefan Cvetkovski, Kate Cantwell, Ian Jacobs, Devon Indig   +5 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Paramedic perceptions of decision-making when managing mental health-related presentations: a qualitative study

BMC Medical Informatics and Decision Making
Background Mental health presentations account for a considerable proportion of paramedic workload; however, the decision-making involved in managing these cases is poorly understood.
Kate Emond, George Mnatzaganian, Michael Savic, Dan I. Lubman, Melanie Bish   +4 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Mental health during ecological crisis: translating and validating the Hogg Eco-anxiety Scale for Argentinian and Spanish populations

BMC Psychology
Background Eco-anxiety is increasingly recognized as a shared experience by many people internationally, encompassing fear of environmental catastrophe and anxiety about ecological crises.
Andrea Rodríguez Quiroga, Juan Segundo Peña Loray, Antonio Moreno Poyato, Juan Roldán Merino, Camila Botero, Laura Bongiardino, Saskia Ivana Aufenacker, Samantha K. Stanley, Tiago Costa, Sílvia Luís, Léan V. O’Brien, Teaghan L. Hogg, Luísa Teixeira-Santos, Lara Guedes de Pinho, Carlos Sequeira, Francisco Sampaio   +15 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Examining the relationships between eco-anxiety, sociodemographic factors, experience of climate events, pro-environmental behaviours, and life satisfaction in young adults

BMC Psychology
Background Climate change and environmental degradation pose significant threats to ecosystems and human well-being, leading to increased eco-anxiety, especially among young adults. Eco-anxiety, characterized by worry and fear about environmental issues,
Juan Roldán Merino, Antonio Moreno Poyato, María Eugenia Malleville, Camila Botero, Arantxa Y. Arredondo, Andrea Rodriguez Quiroga, Tiago Costa, Luísa Teixeira-Santos, Lara Guedes de Pinho, Carlos Sequeira, Sílvia Luís, Francisco Sampaio   +11 more
doaj   +1 more source

Most recent risky drinking session with Australian teenagers

Australian and New Zealand Journal of Public Health, 2017
Objective: Despite declines in Australian alcohol consumption, youth alcohol related harms remain prevalent. These alcohol‐related consequences appear to be driven by a subset of risky drinkers who engage in ‘high intensity’ drinking episodes and are ...
Tina Lam, Simon Lenton, Rowan Ogeil, Lucinda Burns, Alexandra Aiken, Tanya Chikritzhs, William Gilmore, Belinda Lloyd, James Wilson, Dan Lubman, Richard Mattick, Steve Allsop   +11 more
doaj   +1 more source