Results 101 to 110 of about 235,688 (300)
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
A Classifying Procedure for Signaling Turning Points [PDF]
A Hidden Markov Model (HMM) is used to classify an out of sample observation vector into either of two regimes. This leads to a procedure for making probability forecasts for changes of regimes in a time series, i.e. for turning points.
Öller, Lars-Erik, Koskinen, Lasse
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FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Is the Energy Sector at a Turning Point? [PDF]
New research finds that the UK’s energy sector is at a critical turning point, with a deteriorating investment environment putting jobs, tax revenues and regional economies at risk.
Spowage, Mairi
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SensorsThis paper investigates the integration of affective computing techniques using biophysical data to advance emotionally aware machines and enhance child–robot interaction (CRI).
Diego Resende Faria +2 more
doaj +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Evidence presented by Turning Point to the task force reviewing services for drug misusers
, 1995 SIGLEAvailable from British Library Document Supply Centre-DSC:f99/1335 / BLDSC - British Library Document Supply CentreGBUnited ...
Turning Point, London (United Kingdom)
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