Results 171 to 180 of about 6,963,187 (336)

Immunotherapy as a Turning Point in the Treatment of Melanoma Brain Metastases. [PDF]

Discoveries (Craiova), 2023
Fernandes GNC.
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Turning point in COVID-19 severity and fatality during the pandemic: a national cohort study in Qatar. [PDF]

BMJ Public Health, 2023
Chemaitelly H, Ayoub HH, Faust JS, Coyle P, Tang P, Hasan MR, Yassine HM, Al-Khatib HA, Al Thani AA, Al-Kanaani Z, Al-Kuwari E, Jeremijenko A, Kaleeckal AH, Latif A, Shaik RM, Abdul-Rahim HF, Nasrallah GK, Al-Kuwari MG, Butt AA, Al-Romaihi H, Al-Thani MH, Al-Khal A, Bertollini R, Abu-Raddad LJ.   +23 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Fluid-based wearable sensors: a turning point in personalized healthcare. [PDF]

Turk J Chem, 2023
Vural B, Uludağ İ, Ince B, Özyurt C, Öztürk F, Sezgintürk MK.   +5 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Ternary Organic Photovoltaics at a Turning Point: Mechanistic Perspectives on Their Constraints. [PDF]

Nanomaterials (Basel)
Cha HC, Chang KW, Li CF, Jeng SL, Wang YH, Wu HC, Huang YC.   +6 more
europepmc   +1 more source

My Turning Point Tells the Story: A Longitudinal Examination of Greater Episodic Detail and Youth Depressive Symptoms. [PDF]

Res Child Adolesc Psychopathol, 2023
Keats L, Jose P, Salmon K.
europepmc   +1 more source

Turning points [PDF]

Journal of Research in Science Teaching, 1969
openaire   +1 more source