Results 51 to 60 of about 196,605 (263)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Paramedic perceptions of decision-making when managing mental health-related presentations: a qualitative study

BMC Medical Informatics and Decision Making
Background Mental health presentations account for a considerable proportion of paramedic workload; however, the decision-making involved in managing these cases is poorly understood.
Kate Emond, George Mnatzaganian, Michael Savic, Dan I. Lubman, Melanie Bish   +4 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Mental health during ecological crisis: translating and validating the Hogg Eco-anxiety Scale for Argentinian and Spanish populations

BMC Psychology
Background Eco-anxiety is increasingly recognized as a shared experience by many people internationally, encompassing fear of environmental catastrophe and anxiety about ecological crises.
Andrea Rodríguez Quiroga, Juan Segundo Peña Loray, Antonio Moreno Poyato, Juan Roldán Merino, Camila Botero, Laura Bongiardino, Saskia Ivana Aufenacker, Samantha K. Stanley, Tiago Costa, Sílvia Luís, Léan V. O’Brien, Teaghan L. Hogg, Luísa Teixeira-Santos, Lara Guedes de Pinho, Carlos Sequeira, Francisco Sampaio   +15 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Examining the relationships between eco-anxiety, sociodemographic factors, experience of climate events, pro-environmental behaviours, and life satisfaction in young adults

BMC Psychology
Background Climate change and environmental degradation pose significant threats to ecosystems and human well-being, leading to increased eco-anxiety, especially among young adults. Eco-anxiety, characterized by worry and fear about environmental issues,
Juan Roldán Merino, Antonio Moreno Poyato, María Eugenia Malleville, Camila Botero, Arantxa Y. Arredondo, Andrea Rodriguez Quiroga, Tiago Costa, Luísa Teixeira-Santos, Lara Guedes de Pinho, Carlos Sequeira, Sílvia Luís, Francisco Sampaio   +11 more
doaj   +1 more source

Most recent risky drinking session with Australian teenagers

Australian and New Zealand Journal of Public Health, 2017
Objective: Despite declines in Australian alcohol consumption, youth alcohol related harms remain prevalent. These alcohol‐related consequences appear to be driven by a subset of risky drinkers who engage in ‘high intensity’ drinking episodes and are ...
Tina Lam, Simon Lenton, Rowan Ogeil, Lucinda Burns, Alexandra Aiken, Tanya Chikritzhs, William Gilmore, Belinda Lloyd, James Wilson, Dan Lubman, Richard Mattick, Steve Allsop   +11 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source