Results 111 to 120 of about 4,883,737 (287)

Annual report 2001/2002 - Pavee Point [PDF]

, 2003
Pavee Point ...
Pavee Point Travellers Centre
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Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Correction: ‘We don’t live in a harm reduction world, we live in a prohibition world’: tensions arising in the design of drug alerts

Harm Reduction Journal, 2023
Isabelle Volpe, Rita Brien, Jasmin Grigg, Stephanie Tzanetis, Sione Crawford, Tom Lyons, Nicole Lee, Ginny McKinnon, Caitlin Hughes, Alan Eade, Monica J. Barratt   +10 more
doaj   +1 more source

The Strength of a Story: Partnering With a Community Organization to Destigmatize Substance Use Disorder

MedEdPORTAL
Introduction Stigmatizing attitudes held by health care professionals against individuals with substance use disorder (SUD) result in worse clinical outcomes. Story-listening has been shown to help mitigate bias for medical trainees.
Noah Sorkow, Cameron Lauf, Stephen H. Berns   +2 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

A phase III multisite randomised controlled trial to compare the efficacy of cannabidiol to placebo in the treatment of cannabis use disorder: the CBD-CUD study protocol

BMC Psychiatry
Background Cannabis use disorder (CUD) is increasingly common and contributes to a range of health and social problems. Cannabidiol (CBD) is a non-intoxicating cannabinoid recognised for its anticonvulsant, anxiolytic and antipsychotic effects with no ...
Anjali K. Bhardwaj, Llew Mills, Michael Doyle, Arshman Sahid, Mark Montebello, Lauren Monds, Shalini Arunogiri, Paul Haber, Valentina Lorenzetti, Dan I. Lubman, Peter Malouf, Mary E. Harrod, Adrian Dunlop, Tom Freeman, Nicholas Lintzeris   +14 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Correction: Co‑designing drug alerts for health and community workers for an emerging early warning system in Victoria, Australia

Harm Reduction Journal, 2023
Rita Brien, Isabelle Volpe, Jasmin Grigg, Tom Lyons, Caitlin Hughes, Ginny McKinnon, Stephanie Tzanetis, Sione Crawford, Alan Eade, Nicole Lee, Monica J. Barratt   +10 more
doaj   +1 more source

A Classifying Procedure for Signaling Turning Points [PDF]

A Hidden Markov Model (HMM) is used to classify an out of sample observation vector into either of two regimes. This leads to a procedure for making probability forecasts for changes of regimes in a time series, i.e. for turning points.
Öller, Lars-Erik, Koskinen, Lasse
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