Results 51 to 60 of about 6,963,187 (336)

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Secondary building units as the turning point in the development of the reticular chemistry of MOFs

Science Advances, 2018
The SBU approach facilitated the development of permanently porous MOFs with unique properties, chemistry, and applications. The secondary building unit (SBU) approach was a turning point in the discovery of permanently porous metal-organic frameworks ...
Markus J. Kalmutzki, Nikita Hanikel, O. Yaghi   +2 more
semanticscholar   +1 more source

Opioid-related harms and experiences of care among people in justice settings in New South Wales, Australia: evidence from the National Ambulance Surveillance System

Harm Reduction Journal
Background People in justice settings experience higher rates of psychiatric morbidity, including alcohol and drug use disorders, compared with the general population.
Naomi Beard, Michael McGrath, Harry M. X. Lai, James Wilson, Anthony Hew, Amaya Muñoz Labiano, Dan I. Lubman, Rowan P. Ogeil   +7 more
doaj   +1 more source

Twelve-month outcomes of MAKINGtheLINK: A cluster randomized controlled trial of a school-based program to facilitate help-seeking for substance use and mental health problems

EClinicalMedicine, 2020
Background: Young people experiencing mental health problems are often reluctant to seek help, particularly from professionals (i.e., doctors or mental health workers).
Dan I Lubman, Ali Cheetham, Emma Sandral, Rory Wolfe, Catherine Martin, Fiona Blee, Bonita J Berridge, Anthony F. Jorm, Coralie Wilson, Nicholas B. Allen, Lisa McKay-Brown, Jenny Proimos   +11 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Parameter Estimation and Prediction of COVID-19 Epidemic Turning Point and Ending Time of a Case Study on SIR/SQAIR Epidemic Models

Comput. Math. Methods Medicine, 2020
In this paper, the SIR epidemiological model for the COVID-19 with unknown parameters is considered in the first strategy. Three curves (S, I, and R) are fitted to the real data of South Korea, based on a detailed analysis of the actual data of South ...
A. Mehra, M. Shafieirad, Z. Abbasi, I. Zamani   +3 more
semanticscholar   +1 more source

Excitations at the border of a condensate

, 2015
We solve the Bogoliubov--de Gennes equations for an inhomogeneous condensate in the vicinity of a linear turning point. A stable integration scheme is developed using a transformation into an adiabatic basis.
Diallo, Abdoulaye, Henkel, Carsten
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

“Fourteen Dollars for One Beer!” Pre‐drinking is associated with high‐risk drinking among Victorian young adults

Australian and New Zealand Journal of Public Health, 2013
Objective: Pre‐drinking entails consuming alcohol before attending licensed venues. We examined the relationship between pre‐drinking, intention to get drunk and high‐risk drinking among Victorians aged 18–24 years, to consider whether reducing pre ...
Sarah MacLean, Sarah Callinan
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source