Results 81 to 90 of about 6,963,187 (336)

Characteristics of non‐fatal opioid overdoses attended by ambulance services in Australia

Australian and New Zealand Journal of Public Health, 2004
Objective: To examine the feasibility of establishing a database on non‐fatal opioid overdose in order to examine patterns and characteristics of these overdoses across Australia.
Paul Dietze, Damien Jolley, Stefan Cvetkovski, Kate Cantwell, Ian Jacobs, Devon Indig   +5 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Paramedic perceptions of decision-making when managing mental health-related presentations: a qualitative study

BMC Medical Informatics and Decision Making
Background Mental health presentations account for a considerable proportion of paramedic workload; however, the decision-making involved in managing these cases is poorly understood.
Kate Emond, George Mnatzaganian, Michael Savic, Dan I. Lubman, Melanie Bish   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Mental health during ecological crisis: translating and validating the Hogg Eco-anxiety Scale for Argentinian and Spanish populations

BMC Psychology
Background Eco-anxiety is increasingly recognized as a shared experience by many people internationally, encompassing fear of environmental catastrophe and anxiety about ecological crises.
Andrea Rodríguez Quiroga, Juan Segundo Peña Loray, Antonio Moreno Poyato, Juan Roldán Merino, Camila Botero, Laura Bongiardino, Saskia Ivana Aufenacker, Samantha K. Stanley, Tiago Costa, Sílvia Luís, Léan V. O’Brien, Teaghan L. Hogg, Luísa Teixeira-Santos, Lara Guedes de Pinho, Carlos Sequeira, Francisco Sampaio   +15 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The criterion of supernova explosion revisited: the mass accretion history

, 2015
By performing neutrino-radiation hydrodynamic simulations in spherical symmetry (1D) and axial symmetry (2D) with different progenitor models by Woosley & Heger (2007) from 12 $M_{\odot}$ to 100 $M_{\odot}$, we find that all 1D runs fail to produce an ...
Kotake, Kei, Suwa, Yudai, Takiwaki, Tomoya, Yamada, Shoichi   +3 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Ultra-high sensitivity of dual dispersion turning point taper-based Mach-Zehnder interferometer.

Optics Express, 2019
We present here a detailed investigation into the sensitivity of the taper-based Mach-Zehnder interferometer as a function of external refractive index, with particular attention to the dispersion turning point (DTP) and possibilities for ultra-sensitive
Lipeng Sun, Tiansheng Huang, Zihao Yuan, Wenfu Lin, Peng Xiao, Mingjin Yang, Jun Ma, Yang Ran, Long Jin, Jie Li, B. Guan   +10 more
semanticscholar   +1 more source

Molecular Testing in CML between Old and New Methods: Are We at a Turning Point?

Journal of Clinical Medicine, 2020
Molecular monitoring of minimal residual disease (MRD) and BCR-ABL1 kinase domain (KD) mutation testing have a well consolidated role in the routine management of chronic myeloid leukemia (CML) patients, as they provide precious information for ...
S. Soverini, S. Bernardi, S. Galimberti
semanticscholar   +1 more source