Results 51 to 60 of about 1,412,477 (278)
Exploring the turning points in researchers’ lives: using the three-scene storyboarding technique [PDF]
, 2013 This publication sets out an approach to careers work called three scene storyboarding. Storyboarding aims to help researchers to set down their experiences, to think about their careers and to take action based on this reflection.
Bentley, Kieran +2 more
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Earth's Future, 2022 As Earth's warming is driven by anthropogenic activities (e.g., urbanization), land and ocean warming significantly affect the net carbon uptake (NCU) of global ecosystems. However, the driving mechanism of coupled land‐sea warming on the NCU under rapid
Bingxiong Fan, Yangfan Li
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Turning points in life courses structured by co-occurring psychiatric disabilities and addiction
Nordic Social Work ResearchThis article explores the occurrence of turning points in life courses structured by co-occurring psychiatric disabilities and addiction. Persons with co-occurring psychiatric disabilities and addiction tend to live vulnerable lives regarding their ...
Sara Zoric +2 more
doaj +1 more source
Forecasting turning points in Canada [PDF]
Economists have long been involved in the search for a few key indicators that predict the behavior of market economies. For Canada, it has been shown that the yield curve reliably tilts down and that real M1 growth declines before economic contraction ...
Reinhart, Carmen, Reinhart, Vincent
core +1 more source