Results 51 to 60 of about 2,570,686 (307)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Robustness Assessment of the RSD t‐Test for Detecting Trend Turning in a Time Series

Earth and Space Science, 2020
Trend turning (or trend change) is a type of structural change that is common in climate data, and methods for detecting it in time series with multiple turning‐points need to be developed.
Bin Zuo, Zhaolu Hou, Fei Zheng, Lifang Sheng, Yang Gao, Jianping Li   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Turning points during the life of student project teams: A qualitative study

Frontline Learning Research, 2015
In this qualitative study a more flexible alternative of conceptualising changes over time in teams is tested within student project teams. The conceptualisation uses turning points during the lifespan of a team to outline team development, based on work
Elisabeth Raes, Filip Dochy, Eva Kyndt
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Identifying business cycle turning points in real time [PDF]

This paper evaluates the ability of a statistical regime-switching model to identify turning points in U.S. economic activity in real time. The authors work with Markov-switching models of real GDP and employment that, when estimated on the entire post ...
Jeremy Piger, Marcelle Chauvet
core   +2 more sources

Asymptotic Expansions of Eigenvalues of the First Boundary Problem for Singularly Perturbed Second Order Differential Equation with Turning Points

Моделирование и анализ информационных систем, 2016
For singularly perturbed second order equations the dependence of eigenvalues of the first boundary problem on a small parameter at the highest derivative is studied.
S. A. Kashchenko
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Reading Isabella Hammad and Beyond: THE UNSAID – The Point of Recognizing Turning Points, Narratives (Stories), and Strangers

Eidos. A Journal for Philosophy of Culture
The essay is a reflection on Isabella Hammad’s book, Recognizing the Stranger: On Palestine and Narrative (2024). The essay’s approach is to follow the four themes that reflect the title and the subtitle of the book and to draw out what is unsaid from ...
Rory J. Conces
doaj   +1 more source