Results 181 to 190 of about 486,104 (298)

Iterative Use of Regiocomplementary Flavin‐Dependent Halogenases Gives Access to Unique Halogenation Patterns

open access: yesAdvanced Synthesis &Catalysis, EarlyView.
The halide motif is ubiquitous in organic synthesis, facilitating fine‐tuning of molecular properties and functionalization using substitution and cross‐coupling reactions. Combination of different flavin‐dependent tryptophan halogenases enables the installation of novel halogenation patterns on l‐tryptophan, which can be orthogonally addressed in ...
Nicolai Montua   +4 more
wiley   +1 more source

Advances and Outlook of Nickel‐Based MOFs–LDHs Materials for Energy Conversion

open access: yesAdvanced Sustainable Systems, EarlyView.
In this graphical abstract, we present the pivotal gap between the activity and stability parameters as far as intergrated Ni‐based MOF/LDF electrocatalysts are concerned. For large scale application, these two parameters should be optimized and furthermore balanced in order to promote sustainable electrocatalytic hydrogen production.
Lincoln Einstein Kengne Fotso   +4 more
wiley   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

open access: yesAdvanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu   +7 more
wiley   +1 more source

Human Bone‐Derived Endothelial Cells Mediate Bone Regeneration via Distinct Expression of KIT Ligand

open access: yesAdvanced Science, EarlyView.
Bone‐specific endothelial cells (b‐ECs) uniquely express KITLG, which recruits c‐Kit+/CD34+ hematopoietic progenitors (HPCs) to the osteovascular niche, initiating a cascade that culminates in the osteogenic differentiation of bone marrow‐derived mesenchymal stem cells (bm‐MSCs) and subsequent ossification.
Xiang Li   +16 more
wiley   +1 more source

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