Results 241 to 250 of about 1,535,051 (285)

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

The role of leadership in job satisfaction and turnover intention among Navy nurses: a cross-sectional study in Greece. [PDF]

Front Health Serv
Karakolias S, Schiza E.
europepmc   +1 more source

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, EarlyView.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

Coral larval aquaculture: Species-specific survival and microbial dynamics in flow-through systems. [PDF]

PLoS One
Ramsby BD, Brunner R, Barton J, Ferguson S, Grimm C, Hiçyilmaz YC, Bourne DG, Negri AP, Severati A, Sato Y, Wahab MAA.   +10 more
europepmc   +1 more source

Metabologenomic Hallmark‐Based Discovery of Bacterial Thioamides as a New Lead against Drug‐Resistant Pancreatic Cancer

Advanced Science, EarlyView.
A targeted metabologenomic strategy integrating genomic and metabolomic hallmarks enabled the discovery of two new thioamides, thiogochangamides A and B, from bacteria. Their absolute configurations, previously unresolved within the thioviridamide family, were fully assigned through various chemical derivatizations and computational analysis ...
Young Eun Du, Eun Seo Bae, Thinh T. M. Bui, Seok Beom Lee, Dahan Kim, Jin‐Gyeong Park, Yongjoo Park, Soo Yeon Park, Sangwook Kang, Beomsu Lee, Daniel Shin, Yun Pyo Kang, In‐Gyun Lee, Dae‐Duk Kim, Seokhee Kim, Suckchang Hong, Kyuho Moon, Sang Kook Lee, Dong‐Chan Oh   +18 more
wiley   +1 more source

Impact of patient safety culture on resilience and turnover intention: a multi-site study. [PDF]

BMC Health Serv Res
Innab A, Alfar Z, Shaqiqi W, Alammar K, Hakamy E.   +4 more
europepmc   +1 more source

Consistent Trait Patterns in a Hyper Diverse Moth Clade Along a Western Himalayan Elevational Gradient. [PDF]

Ecol Evol
Dey P.
europepmc   +1 more source

The effects of dairy products containing <i>Lactobacillus bulgaricus</i> and <i>Streptococcus thermophilus</i> on bone turnover biomarkers and bone mineral density: a pilot trial study. [PDF]

Front Nutr
Rueangsri N, Booranasuksakul U, Thanomsridetchai N, Chutoam P, Prapkree L, Singhato A.   +5 more
europepmc   +1 more source