Results 241 to 250 of about 511,586 (292)

PTG‐Dependent Glycogen Metabolic Dysfunction Drives Impaired Adipose Browning: A Novel Mechanism Linking PM2.5 to Metabolic Disorders

Advanced Science, EarlyView.
This study provides the first evidence that PM2.5 impairs iWAT browning via PTG‐mediated glycogen metabolism disruption, which is initiated by ADRB3 inhibition and subsequently triggers VEGFB upregulation. It thereby delineates the ADRB3‐PTG‐VEGFB axis as central to PM2.5‐induced metabolic dysfunction and identifies adipose glycogen metabolism as a ...
Limin Wang, Renjie Hu, Yanxi Chai, Ping He, Sanduo Li, Lisha Zhao, Wenbin Zhao, Lu Zhang, Li Qin, Ran Li, Xiaoli Hou, Qinghua Sun, Cuiqing Liu   +12 more
wiley   +1 more source

A Dynamic Gate Enables Regioselective Hydroxylation of Free Arginine by a Non‐Canonical Heme Enzyme

Advanced Science, EarlyView.
The YqcI/YcgG enzyme AglA employs a unique “sandwich” fold and a dynamic gating mechanism to selectively hydroxylate AMPn‐Arg at Nε. Site‐directed mutations reprogram regioselectivity or enable activity on free arginine by altering hydrogen‐bond networks, precisely positioning substrates.
Yuan Sun, Chao Dou, Weizhu Yan, Pengpeng Chen, Lu Zhang, Dan Zhou, Yanhui Zheng, Zhaolin Long, Shoujie Li, Xiaoqing Xu, Qiuxia Huang, Xiaofeng Zhu, Wei Cheng   +12 more
wiley   +1 more source

Norepinephrine and dopamine Imbalance in the medial frontal gyrus from patients with Alzheimer's disease. [PDF]

IBRO Neurosci Rep
Yurtsever ZN, Capuani S, Fratini M, Nicaise C, Salman Y, Hanseeuw B, Carlesimo GA, Latagliata EC, Coccurello R.   +8 more
europepmc   +1 more source

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

Advanced Science, EarlyView.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu, Keda Yu, Lei Liu, Qin Wang, Xiaohui Wu, Yihai Chen, Guozheng Li, Xin Zhang, Bo Wei, Zitong Fu, Abiyasi Nanding, Zuxianglan Zhao, Lingbing Yang, Xingda Zhang, Jianyu Wang, Wantong Sun, Yi Hao, Zhongyi Cheng, Xiaojiang Cui, Hao Wu, Da Pang   +20 more
wiley   +1 more source

Exploring the mediating effect of burnout between fear of COVID-19, job-related stress and turnover intention among elderly care workers. [PDF]

BMC Health Serv Res
Németh Z, Deák P, Makai A, Hock M.
europepmc   +1 more source

Perceptions of Supervisor Communication Behavior and the Effect on Employee Satisfaction and Anticipated Turnover in a Group of Rotating Shift Workers

, 1985
Thomas B. Barnes
openalex   +1 more source

Application of the SWARA-TOPSIS method for prioritizing turnover intention factors among nurses: a case study in an Isfahan hospital, Iran. [PDF]

BMC Nurs
Naeini MJ, Shakerian M, Yazdanirad S, Mousavi SM.   +3 more
europepmc   +1 more source

Postprandial Glucagon Metabolism in Healthy and Type 1 Diabetes. [PDF]

Diabetes
Ruchi FNU, Schiavon M, Pandey A, Dalla Man C, Cobelli C, Basu R, Basu A.   +6 more
europepmc   +1 more source