Results 71 to 80 of about 983,506 (283)
Advanced Science, EarlyView.Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen +8 more
wiley +1 more source
Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis
Advanced Science, EarlyView.ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai +15 more
wiley +1 more source
Advanced Science, EarlyView.The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang +9 more
wiley +1 more source
Continuité, canonicité et complétude dans Doctor Who
TV Series, 2014 This article explores the complex relation to continuity in the British show Doctor Who (BBC, 1963-1989, 2005-), by looking into its multi-auctoriality from a diachronic and then synchronic point of view, and by detailing a fictional world dispersed ...
Florent Favard
doaj +1 more source
Risk factor identification and prevention of osteoporosis in the primary care setting [PDF]
, 2006 On one of her visits, MB Borg, a 54 year old lady, showed concern about her risk of developing osteoporosis. Lately, she had been listening to a series of radio and TV programmes on this matter where particular emphasis was put on bone density scans. She
De Gabriele, Patricia
core
Advanced Science, EarlyView.This study introduces a multifunctional hydrogel coating (Lap‐CMCSMA/GelMA@SeNPs) that scavenges ROS, modulates immune responses, and shows strong antibacterial activity. It effectively restores the peri‐implant microenvironment. The coating exhibits excellent biocompatibility and promotes osteogenic differentiation.
Su Jiang +7 more
wiley +1 more source
« Reality is out there » : le néo-réalisme fantastique dans quelques épisodes de The X-Files
TV Series, 2012 From the series X-Files, what often stands out is the paranoid structure around which the continuity of the principal storyline is constructed — the conspiracy theory that structures, or at least provides unity, over the course of seasons, beyond the ...
Emmanuelle Delanoë-Brun
doaj +1 more source
The Role of Ionic Liquids at the Biological Interfaces in Bioelectronics
Advanced Science, EarlyView.Ionic liquids (ILs) are highlighted as key artificial ionic materials that bridge biological ion‐based signaling and electronic devices. By understanding their composition, structure, function relationships, and mechanisms, ILs can advance from high performance electrolyte to core materials enabling integrated, multifunctional bioelectronics for ...
Yeong‐sinn Ye +5 more
wiley +1 more source
Monstrueuse convergence ? Penny Dreadful, ou la littérature à l’épreuve de la transmédialité
TV Series, 2017 Although it was labelled a monster mash upon its release, Penny Dreadful (Showtime, 2014) offers a subtle combination of literature and film. Indeed, the series strangely blends Shakespeare with The Exorcist, Mary Shelley’s Frankenstein with The Phantom ...
Sébastien Lefait
doaj +1 more source
Comms Review Series: TV Producers Want More Regulation [PDF]
, 2012 In their submissions to the Government’s review of the Communications Act, independent production houses are calling for the regulatory model governing PSB funded television content to be extended to new sectors of the economy.
Tambini, Damian
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