Results 191 to 200 of about 49,659 (292)

Obesity is associated with increased brain glucose uptake and activity but not neuroinflammation (TSPO availability) in monozygotic twin pairs discordant for BMI-Exercise training reverses increased brain activity. [PDF]

Diabetes Obes Metab
Hentilä J, Tuisku J, Ojala R, Sun L, Lietzén MS, Virtanen H, Lautamäki R, Koskensalo K, Nummenmaa L, Löyttyniemi E, Helin S, Pietiläinen KH, Kaprio J, Lahti L, Malm T, Rinne JO, Hannukainen JC.   +16 more
europepmc   +1 more source

Defect Dynamics and Solution‐Processed Interconnects in Perovskite‐Organic Tandem Solar Cells

Advanced Science, EarlyView.
In this study, we identify the underlying cause of efficiency losses in WBG perovskites, which is ascribed to the presence of mobile defects distributed at surface regions. We further employ effective passivation agent with functional chemical groups to facilitate the healing of the mobile defects, thereby enhancing the VOC to 1.35 V and champion ...
Yingjie Hu, Qianyi Li, Kaifeng Jing, Jiangsheng Yu, Fuyi Zhou, Zhenhai Ai, You Chen, Yue Zhao, Yijia Zhang, Zhenyi Ni, Yang Bai, Gang Li, Guang Yang   +12 more
wiley   +1 more source

Amniotic Fluid Embolism in Donor Egg Twin Pregnancy: A Clinical Challenge in Critical Care. [PDF]

Cureus
Owies A, Attia A, John HT, Gajjar R, Abbas M.   +4 more
europepmc   +1 more source

Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

Advanced Science, EarlyView.
Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang, Tingting Qu, Qibing Sun, Ran Li, Junfei Dong, Yuming Du, Ziyin Xuan, Lei Wang, Hanli Li, Jianyun Sun, Fangliang Chen, Jinshuai Liu, Zifan Yang, Jianxiang Lei, Qian Yang, Bin Wang, Zhiming Zhou, Yu Wang   +17 more
wiley   +1 more source

Attention-deficit/hyperactivity disorder (ADHD) in adults: evidence base, uncertainties and controversies. [PDF]

World Psychiatry
Cortese S, Bellgrove MA, Brikell I, Franke B, Goodman DW, Hartman CA, Larsson H, Levin FR, Ostinelli EG, Parlatini V, Ramos-Quiroga JA, Sibley MH, Tomlinson A, Wilens TE, Wong ICK, Hovén N, Didier J, Correll CU, Rohde LA, Faraone SV.   +19 more
europepmc   +1 more source

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

How are children's perceptions of the home environment associated with a general psychopathology factor across childhood? [PDF]

J Child Psychol Psychiatry
Nejand JK, Malanchini M, Voronin I, Eley TC, Rimfeld K.   +4 more
europepmc   +1 more source

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, EarlyView.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source

Longitudinal development of sex differences in the limbic system is associated with age, puberty and mental health. [PDF]

Commun Biol
Matte Bon G, Walther J, Comasco E, Derntl B, Kaufmann T.   +4 more
europepmc   +2 more sources

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source