Results 51 to 60 of about 7,310 (240)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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IEEE AccessThis paper presents a proof-of-concept digital twin designed to enhance industrial process monitoring and maintenance through real-time and bidirectional communication.
Bulent Soykan +2 more
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The Role of the Microbiome in Driving RA-Related Autoimmunity
Frontiers in Cell and Developmental Biology, 2020 Once referred to as “normal commensal flora” the human microbiome plays an integral role between health and disease. The host mucosal surface replete with a multitude of immune cells is a vast arena constantly sensing and responding to antigen ...
Cristopher M. Rooney +4 more
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Equations for a potential algebraic approach to the twin prime conjecture. Addendum to: "On the numbers that determine the distribution of twin primes" [PDF]
Surveys in Mathematics and its ApplicationsThis is an Addendum to: Article: On the numbers that determine the distribution of twin primes Author: Antonie Dinculescu Published in: Surveys in Mathematics and its Applications, 13 (2018), 171–181. Full text:
Antonie Dinculescu
doaj
Effective theory of flavor for Minimal Mirror Twin Higgs
Journal of High Energy Physics, 2017 We consider two copies of the Standard Model, interchanged by an exact parity symmetry, P. The observed fermion mass hierarchy is described by suppression factors ϵ n i $$ {\upepsilon}^{n_i} $$ for charged fermion i, as can arise in Froggatt-Nielsen and ...
Riccardo Barbieri +2 more
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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The origin of microtwinning in HAYNES® 244® superalloy
Communications MaterialsSuperalloys exhibit varying deformation mechanisms at differing temperatures and strain rates. The HAYNES® 244® superalloy stands out due to its consistent mechanism of planar fault formation.
Victoria Tucker +6 more
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source