Results 81 to 90 of about 7,310 (240)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Predicting Maximal Gaps in Sets of Primes
Mathematics, 2019 Let q > r ≥ 1 be coprime integers. Let P c = P c ( q , r , H ) be an increasing sequence of primes p satisfying two conditions: (i) p ≡ r (mod q) and (ii) p starts a prime k-tuple with a given pattern H ...
Alexei Kourbatov, Marek Wolf
doaj +1 more source
Japanese Journal of Mathematics, 2019 In the last fifteen years or so there has been a wealth of results and methods dealing with small differences between primes (in what follows \(p\) with or without subscripts denotes primes). The author of this impressive overview paper is one of the mathematicians who has made some of the most important contributions in this field.
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
, 2023 Abstract The Twin Prime conjecture first proposed by French mathematician Alphonse de Polignac in the year 1846 remains unproven until now. This paper sets out to prove the Twin Prime conjecture by creating a system of equations and finding both a y element of ℕ, (y ϵ ℕ) and a y element of k, (y ϵ k) to find the twin prime values and ...
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Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
A Relation between Prime Numbers and Twin Prime Numbers [PDF]
Mathematical and Computational Applications, 2001 Every mathematician has been concerned with prime numbers, and has metwith mysterious surprises about them. Besides intuition, using empirical methods has an important role to findrelations between prime numbers. A relation between any prime numberand any twin prime number has been obtained.
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Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Irregularities in the Distribution of Primes and Twin Primes [PDF]
Mathematics of Computation, 1975 The maxima and minima of ⟨ L ( x ) ⟩ − π ( x ) , ⟨ R ( x ) ⟩ − π ( x ) \langle L(x)\rangle - \pi (x),\langle R(x)\rangle - \pi (x) , and ⟨ L ...
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