Results 1 to 10 of about 346,692 (290)

Gender differences in like-sex middle-aged twins: an extended network analysis of depressive symptoms, cognitive functions and leisure activities [PDF]

European Psychiatry
Background Depression affects twice as many women as men. Risk factors for depression certainly impact this difference, but their strong interconnectedness challenges the assessment of standalone contributions.
Daiyan Zhang, Maria Semkovska
doaj   +2 more sources

Comparison of Genomic and Epigenomic Expression in Monozygotic Twins Discordant for Rett Syndrome.

PLoS ONE, 2013
Monozygotic (identical) twins have been widely used in genetic studies to determine the relative contributions of heredity and the environment in human diseases.
Kunio Miyake, Chunshu Yang, Yohei Minakuchi, Kenta Ohori, Masaki Soutome, Takae Hirasawa, Yasuhiro Kazuki, Noboru Adachi, Seiko Suzuki, Masayuki Itoh, Yu-Ichi Goto, Tomoko Andoh, Hiroshi Kurosawa, Mitsuo Oshimura, Masayuki Sasaki, Atsushi Toyoda, Takeo Kubota   +16 more
doaj   +2 more sources

Monozygotic twins discordant for juvenile dermatomyositis: clinical, serological and gene expression studies [PDF]

Pediatric Rheumatology Online Journal
Background Juvenile Dermatomyositis (JDM) is a rare pediatric autoimmune disease involving a combination of environmental and genetic susceptibility factors.
Lauren M. Pachman, Amer Khojah, Gabrielle Morgan, Wilfredo Marin, Judith James, Sabah Kadri, Kai Lee Yap   +6 more
doaj   +2 more sources

Identical twins carry a persistent epigenetic signature of early genome programming

Nature Communications, 2021
The mechanisms underlying how monozygotic (or identical) twins arise are yet to be determined. Here, the authors investigate this in an epigenome-wide association study, showing that monozygotic twinning has a characteristic DNA methylation signature in ...
Jenny van Dongen, Scott D. Gordon, Allan F. McRae, Veronika V. Odintsova, Hamdi Mbarek, Charles E. Breeze, Karen Sugden, Sara Lundgren, Juan E. Castillo-Fernandez, Eilis Hannon, Terrie E. Moffitt, Fiona A. Hagenbeek, Catharina E. M. van Beijsterveldt, Jouke Jan Hottenga, Pei-Chien Tsai, BIOS Consortium, Genetics of DNA Methylation Consortium, Josine L. Min, Gibran Hemani, Erik A. Ehli, Franziska Paul, Claudio D. Stern, Bastiaan T. Heijmans, P. Eline Slagboom, Lucia Daxinger, Silvère M. van der Maarel, Eco J. C. de Geus, Gonneke Willemsen, Grant W. Montgomery, Bruno Reversade, Miina Ollikainen, Jaakko Kaprio, Tim D. Spector, Jordana T. Bell, Jonathan Mill, Avshalom Caspi, Nicholas G. Martin, Dorret I. Boomsma   +37 more
doaj   +2 more sources

Examining the Utility of the Mammalian Methylation Array for Pan-Mammalian Analysis of Monozygotic Twinning [PDF]

Epigenomes
Background/Objectives: Human identical twins are born at a rate of 3–4 per 1000 live births. Many other mammals also occasionally produce monozygotic twins, referred to as sporadic polyembryony. The underlying mechanisms are unknown.
Jenny van Dongen, Charles E. Breeze, Twinning Genetics Consortium   +2 more
doaj   +2 more sources

Chromosome 22q11.2 microdeletion in monozygotic twins with discordant phenotype and deletion size

Molecular Cytogenetics, 2012
We report on a pair of male monozygotic twins with 22q11.2 microdeletion, discordant phenotype and discordant deletion size. The second twin had findings suggestive of DiGeorge syndrome, while the first twin had milder anomalies without any cardiac ...
Halder Ashutosh, Jain Manish, Chaudhary Isha, Varma Binuja   +3 more
doaj   +2 more sources

Epigenetic discrimination of Lebanese monozygotic and dizygotic twins: Summarized notes in a single paper [PDF]

International Research Journal of Science, Technology, Education, and Management, 2021
Monozygotic twins’ differentiation is worldwide limited due to the fact that they share the same genotype. For forensic purposes, many studies involving monozygotic twins were accomplished.
Paula Romanos, Jamilah Borjac
doaj   +1 more source

The Impact of Environmental and Genetic Factors on Bone Quality in Monozygotic and Dizygotic Twins

Biomedicines, 2022
The purpose of the research was to assess the genetic and environmental influences on bone properties. One hundred thirty-two pairs of twins (99/33 monozygotic/dizygotic) underwent anthropometric measurements and phalangeal quantitative ultrasound (DBM ...
Elżbieta Tabor, Małgorzata Bach, Aleksandra Werner, Bogna Drozdzowska, Wojciech Pluskiewicz   +4 more
doaj   +1 more source

Bivariate genetic modelling of the response to an oral glucose tolerance challenge: A gene x environment interaction approach [PDF]

, 2009
AIMS/HYPOTHESIS: Twin and family studies have shown the importance of genetic factors influencing fasting and 2 h glucose and insulin levels. However, the genetics of the physiological response to a glucose load has not been thoroughly investigated ...
AJ Hanley, B Benyamin, D Lann, E Zeggini, EJ Geus De, EJ Mayer, G. F. Liu, H Snieder, H Snieder, H Snieder, H. Riese, H. Snieder, J Baird, JM McCaffery, K Schousboe, L Gaal Van, M Lehtovirta, M Lehtovirta, M. Mangino, MCBS Neale, MCCL Neale, NJ Samani, NY Souren, P Poulsen, P Poulsen, Q Qiao, R. P. Stolk, S Katoh, S. D. O’Dell, SM Haffner, T Andrew, T. D. Spector, TD Gould, TD Spector, The DECODE Study Group, TM Frayling, World Health Organization   +36 more
core   +16 more sources

The Surviving Monozygotic Twin [PDF]

Obstetrical & Gynecological Survey, 1986
It has been suggested that because of vascular interchange between the monozygous twins vascular disruptions from a deceased cotwin with disseminated intravascular coagulation causes embolisation in the surviving twin. This study reports six cases in which all the surviving monozygous twins had central nervous system infarcts and three had multiple ...
H. Preston, V. Y. H. Yu, W. Szymonowicz
openaire   +4 more sources