Results 91 to 100 of about 561,765 (333)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Molecular design of dynamically thermoresponsive biomaterials

Science and Technology of Advanced Materials
Dynamically thermoresponsive biomaterials, particularly those utilizing poly(N-isopropylacrylamide) (PNIPAAm), have attracted much attention in biomedical applications due to their reversible phase transition near body temperature.
Jun Kobayashi, Masamichi Nakayama, Kenichi Nagase   +2 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Fabrication of Three-Dimensional HepG2 Liver Tissue by Centrifugation

Tokyo Women's Medical University Journal
Background: We previously developed a rapid three-dimensional (3-D) tissue fabrication method using centrifugation. In this study, we fabricated 3-D HepG2 liver tissues using a scaffold-free centrifugation method and analyzed them biochemically. Methods:
Mai Ogawa, Yuji Haraguchi, Tatsuya Shimizu   +2 more
doaj   +1 more source

The Fertility Pattern of Twins and the General Population Compared: Evidence from Danish Cohorts 1945-64 [PDF]

Twin studies provide an important possibility for demographers to analyze patterns of heritability and to estimate structural models with controls for endowments. These possibilities are increasingly used in the context of fertility and related behaviors.
Axel Skytthe, Hans-Peter Kohler, Kaare Christensen, Lisbeth B. Knudsen   +3 more
core  

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Risk for surviving twin after fetal death of co-twin in twin–twin transfusion syndrome

Obstetrics & Gynecology, 1998
To determine neonatal outcome of surviving twins in pregnancies complicated by twin-twin transfusion syndrome and fetal deaths of co-twins.We retrospectively reviewed medical records of 11 women seen during 1990-1996 in our hospital who had pregnancies complicated by twin-twin transfusion syndrome and death of one fetus.The median interval between ...
Nijhuis, J.G., Heteren, C.F. van, Semmekrot, B.A., Mulders, L.G.M., Berg, P.P. van den   +4 more
openaire   +4 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Tracking Chart 2009 Twins Enterprise Inc, [PDF]

, 2009
Outlines the specific problems that were found by monitors and the action taken by Twins Enterprise Inc in response to an FLA audit of a factory in ...
Fair Labor Association
core   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source