Results 131 to 140 of about 561,765 (333)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón +8 morewiley +1 more sourceNicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu +5 morewiley +1 more sourcePARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer +21 morewiley +1 more sourceHair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes [PDF]
, 2017 Liz Rietschel, Fabian Streit, Gu Zhu, Kerrie McAloney, Josef Frank, Baptiste Couvy‐Duchesne, Stephanie H. Witt, Tina M. Binz, Jennifer L. Bolton, Caroline Hayward, Neşe Direk, Anna Anderson, Jennifer E. Huffman, James F. Wilson, Harry Campbell, Igor Rudan, Alan F. Wright, Nicholas D. Hastie, Sarah H. Wild, Fleur P. Velders, Albert Hofman, André G. Uitterlinden, Jari Lahti, Katri Räikkönen, Eero Kajantie, Elisabeth Widén, Aarno Palotie, Johan G. Eriksson, Marika Kaakinen, Marjo‐Riitta Järvelin, Nicholas J. Timpson, George Davey Smith, Susan M. Ring, David M. Evans, Beaté St Pourcain, Toshiko Tanaka, Yuri Milaneschi, Stefania Bandinelli, Luigi Ferrucci, Pim van der Harst, Judith G.M. Rosmalen, Stephen J. L. Bakker, Niek Verweij, Robin P. F. Dullaart, Anubha Mahajan, Cecilia M. Lindgren, Andrew P. Morris, Lars Lind, Erik Ingelsson, Laura N. Anderson, Craig E. Pennell, Stephen J. Lye, Stephen G. Matthews, Joel Eriksson, Dan Mellström, Claes Ohlsson, Jackie F. Price, Mark W. J. Strachan, Rebecca M. Reynolds, Henning Tiemeier, Stephan Ripke, Manuel Mattheisen, Abdel Abdellaoui, Mark J. Adams, Esben Agerbo, Tracy Air, Till F. M. Andlauer, Silviu‐Alin Bacanu, Marie Bækvad‐Hansen, Aartjan T.F. Beekman, David A. Bennett, Kenneth I. Berger, Tim B. Bigdeli, Jonas Bybjerg‐Grauholm, Enda M. Byrne, Na Cai, Enrique Castelao, Toni‐Kim Clarke, Jonathan R. I. Coleman, CPTAC Clinical Proteomic Tumor Analysis Consortium, Nick Craddock, Udo Dannlowski, Gareth E. Davies, Gail Davies, Eco J. C. de Geus, Philip L. De Jager, Ian J. Deary, Franziska Degenhardt, Erin C. Dunn, Erik A. Ehli, Thalia C. Eley, Valentina Escott‐Price, Tōnu Esko, Hilary K. Finucane, Michael Gill, Scott D. Gordon, Jakob Grove, Lynsey S. Hall, Thomas Folkmann Hansen, Christine Søholm Hansen +99 moreopenalex +1 more sourceCharacterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane +9 morewiley +1 more source
