Results 211 to 220 of about 561,765 (333)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Monochorionic-twin-on-a-chip for investigating fetal organ growth and metabolism. [PDF]

Microsyst Nanoeng
Ran R, Dong X, Yang Y, Shakeel S, Liu X, Saffery R, Yang J, Han TL.   +7 more
europepmc   +1 more source

TT-CNN: a twin-tower convolutional spatial learned cost model for end-to-end runtime prediction

bei, xu
openalex   +1 more source

Heritability of face shape in twins: a preliminary study using 3D stereophotogrammetry and geometric morphometrics

, 2013
Seth M. Weinberg, Trish E. Parsons, Mary L. Marazita, Brion S. Maher   +3 more
openalex   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Microstructure Evolution and Plastic Deformation Mechanism of Cold Rolling Deformation of Micro/Nano Pure Electrolytic Nickel. [PDF]

Materials (Basel)
Zhang H, Qiao J, Yang H, Xu Y, Xia T.
europepmc   +1 more source

'I Get Off on Intense Atmospheres': An Interview with Gazelle Twin

, 2014
Guy Mankowski, E Bernholz
openalex  

Environmental Data and Digital Twins for Road Traffic Safety in Rural Areas

Volkovičs, Roberts, Bambāns, Viesturs, Majore, Ginta   +2 more
openalex   +1 more source

MULTIGRAPH IS: Part 1. A FORMAL DESCRIPTION OF RAILWAY INFRASTRUCTURE FOR THE DIGITAL TWIN OF THE ETCS APPLICATION

, 2023
Andrzej Kochan, P. Folęga, Remigijus SKIRKUS, Гинтаутас Бурейка   +3 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source