Results 211 to 220 of about 753,593 (350)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A novel digital twin strategy to examine the implications of randomized clinical trials for real-world populations. [PDF]

NPJ Digit Med
Thangaraj PM, Shankar SV, Huang S, Nadkarni GN, Mortazavi BJ, Oikonomou EK, Khera R.   +6 more
europepmc   +1 more source

Renal Transplantation in Identical Twins [PDF]

, 1963
Brittain, RS, Coppinger, WR, Starzl, TE, Stonnington, OG, Waddell, WR   +4 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

From prediction to intervention: causal digital twins for personalized clinical decision support. [PDF]

J Transl Med
Vallée A.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Medical Digital Twin Technology for Interoperability: Challenges and Opportunities. [PDF]

Biomed Eng Comput Biol
Tengku Alang TAI, Lee YY, Tan TS, Mokhtar AM.   +3 more
europepmc   +1 more source

Genetic Determinants of the Gut Microbiome in UK Twins.

Cell Host and Microbe, 2016
Julia Goodrich, Emily R. Davenport, M. Beaumont, M. Jackson, R. Knight, C. Ober, T. Spector, J. Bell, A. Clark, R. Ley   +9 more
semanticscholar   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A decade of innovation in healthcare: Automation, bio-printing and digital twin technologies for personalized therapies. [PDF]

Int J Pharm X
Ghavami D, Giulietti N, Sandri G, Giberti H.   +3 more
europepmc   +1 more source