This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Succinate-driven virulence enhancement in hypervirulent <i>Klebsiella pneumoniae</i> via DcuSR two-component system. [PDF]
Zhong G +12 more
europepmc +1 more source
Coarsening in (nearly) mass-conserving two-component reaction diffusion systems
Fridtjof Brauns +4 more
openalex +1 more source
Erratum: Born-Oppenheimer study of two-component few-particle systems under one-dimensional confinement [Phys. Rev. A89, 052706 (2014)] [PDF]
N. P. Mehta
openalex +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Correction: Genome-wide identification and functional characterization of the two-component system gene family in petunia reveals roles in hormone signaling and stress response. [PDF]
Dai B +6 more
europepmc +1 more source
Bethe-ansatz analysis of near-resonant two-component systems in one dimension [PDF]
Tianhao Ren, I. L. Aleǐner
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Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
A small periplasmic protein governs broad physiological adaptations in Vibrio cholerae via regulation of the DbfRS two-component system. [PDF]
Nguyen E +8 more
europepmc +1 more source

