Results 201 to 210 of about 2,123,405 (317)

A nitric oxide-sensing two-component system regulates a range of infection-related phenotypes in <i>Burkholderia pseudomallei</i>. [PDF]

mSphere
Scurlock MW, Michell SL, Porter SL.
europepmc   +1 more source

The MtrAB two-component system controls antibiotic production in Streptomyces coelicolor A3(2)

, 2017
Nicolle F. Som, Daniel Heine, Neil A. Holmes, Felicity Knowles, Govind Chandra, Ryan F. Seipke, Paul A. Hoskisson, Barrie Wilkinson, Matthew I. Hutchings   +8 more
openalex   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Small excretory-secretory proteins of Acanthamoeba castellanii genotype T4 upregulate the expression of capsule-associated genes via the Rcs two-component system in Klebsiella pneumoniae. [PDF]

Parasit Vectors
Chuang YC, Hsieh HY, Tsai CM, Wang YJ.
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Correction: The two-component system CpxAR is required for the high potassium stress survival of <i>Actinobacillus pleuropneumoniae</i>. [PDF]

Front Microbiol
Wan J, Zhang R, Jia Y, Xie T, Dai L, Yao Q, Zhang W, Xiao H, Gao X, Huang J, Bei W, Liu F.   +11 more
europepmc   +1 more source

An investigation into the structure and function of VanS proteins involved in the two-component VanS/VanR regulatory system controlling antibiotic resistance [PDF]

, 2014
Richard J. Edwards
openalex  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A <i>Campylobacter jejuni</i> sensor phosphatase-driven two-component system integrates metabolic phosphodonors as cues in signal transduction. [PDF]

Proc Natl Acad Sci U S A
Ruiz N, Hendrixson DR.
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source