Results 61 to 70 of about 1,537,923 (347)

Trametinib in Adults with Neurofibromatosis Type 1‐Related Symptomatic Plexiform Neurofibromas

Annals of Neurology, EarlyView.
Objective Mitogen‐activated protein kinase kinase inhibitors have shown promising results in treatment of plexiform neurofibromas in neurofibromatosis type 1 patients, but data in adults are limited. The aim of this phase 2 study was to investigate the efficacy and safety of trametinib in adults with neurofibromatosis type 1.
D. Christine Noordhoek, David F. Hanff, Pim J. French, Sarah A. van Dijk, Erik A.C. Wiemer, Olivier C. Manintveld, Martin J. van den Bent, Walter Taal   +7 more
wiley   +1 more source

Engineering Ultrasound Contrast Agents for Targeted Therapeutics: A Theranostic Approach to Drug Delivery, Gene Therapy, and Immunomodulation

Advanced NanoBiomed Research, EarlyView.
Ultrasound contrast agents, including microbubbles and nanobubbles, transform imaging and targeted therapy through precise engineering of size, shell composition, and surface properties. This review explores how these innovations enable tissue‐specific delivery, enhance therapeutic efficacy, and extend applications from vascular imaging to tumor ...
Ashkan Seza, Kimia Mozahheb Yousefi, Sara Minaeian   +2 more
wiley   +1 more source

Adipocytes in Aortic Stenosis: Association With Clinical and Morphological Indices

Clinical Anatomy, EarlyView.
ABSTRACT Recently, great attention has been given to understanding the new pathogenetic mechanisms underlying aortic stenosis (AS). The study aims to understand the role of mature adipocytes in AS and their association with histologic, clinical, and echocardiographic data, an area previously overlooked in AS research.
Elena Zoico, Tanaz Saatchi, Silvia Urbani, Vanni Rizzatti, Gloria Mazzali, Francesco Fantin, Silvia Faccioli, Alessandro Gavras, Mauro Zamboni, Anna Giani   +9 more
wiley   +1 more source

Prevention and Management of Percutaneous Coronary Intervention‐Related Complications: Assessing the Impact of Simulation‐Based Learning and Human Factors Training

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Complications of percutaneous coronary intervention (PCI) remain infrequent but are associated with a risk of serious injury or death. The techniques and devices required to manage them may be unfamiliar or unavailable to operators.
Junichi Fukamizu, Tobias MacCarthy, Ikuo Shimizu, Shigeki Ariura, Ryouta Tanetani, Shouta Arahira, Manabu Tamura, Ken Masamune, Kalaivani Mahadevan, Nitin Chandramohan, Thomas Hovasse, Jacques Monsegu, James Nolan, Joelle Kefer, Piotr Musialek, Martin Oberhoff, Michael Haude, Hakim Benamer, Olivier Muller, Patrick A. Calvert, Satoru Sumitsuji, Peter O'Kane, Gabor Toth, Thomas Cuisset, William Wijns, Thomas W. Johnson   +25 more
wiley   +1 more source

Comparison of left ventricular ejection fraction values obtained using invasive contrast left ventriculography, two-dimensional echocardiography, and gated single-photon emission computed tomography

SAGE Open Medicine, 2016
Objectives: Left ventricular ejection fraction can be measured by a variety of invasive and non-invasive cardiac techniques. This study assesses the relation of three diagnostic modalities to each other in the measurement of left ventricular ejection ...
Nadish Garg, Thomas Dresser, Kul Aggarwal, Vishal Gupta, Mayank K Mittal, Martin A Alpert   +5 more
doaj   +1 more source

Three-dimensional echocardiographic assessment of atrial septal defects

Annals of Cardiac Anaesthesia, 2015
Echocardiography provides a useful tool in the diagnosis of many congenital heart diseases, including atrial septal defects, and aids in further delineating treatment options.
Charles German, Navin C Nanda
doaj   +1 more source

Left Ventricular Outflow Tract Geometry as a Predictor of Permanent Pacemaker Implantation After Transcatheter Aortic Valve Implantation Using the Evolut Series

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Predicting the need for permanent pacemaker implantation (PPM) after transcatheter aortic valve implantation (TAVI) is crucial for procedural planning and patient counseling. Aims To evaluate whether left ventricular outflow tract (LVOT) morphology, specifically a tapered configuration, predicts conduction disturbances requiring PPM
Mahmoud Abdelshafy, Angela McInerney, Ahmed Elmeanawy, Paolo Alberto Del Sole, Max Wagener, Hatem Helal, Mahmoud Abozaid, Ashraf Alamir, Tamer Fouad, Alsayed Almarghany, Briain MacNeill, Osama Soliman, Darren Mylotte, Mohammad Abdelghani   +13 more
wiley   +1 more source

Assessment right atrial thrombus by real-time three dimensional transthoracic echocardiography in patient with dilated cardiomyopathy

Cardiovascular Ultrasound, 2011
We report a case of a 52-year-old patient with dilated cardiomyopathy who presented with worsening heart failure. Two-dimensional transthoracic echocardiography and real-time three dimensional transthoracic echocardiography showed severe dilated cardiac ...
Zhang Qing, Li Hui, Bai Wenjuan, Rao Li
doaj   +1 more source

Heterozygous Med13l mice recapitulate a developmental growth delay and craniofacial anomalies seen in MED13L syndrome

Developmental Dynamics, EarlyView.
Abstract Background Gene transcription is crucial for embryo and postnatal development and is regulated by the Mediator complex. Mediator is comprised of four submodules, including the kinase submodule (CKM). The CKM consists of MED13, MED12, CDK8, and CCNC.
Anna K. Leinheiser, Timothy T. Nguyen, Kayla M. Henry, Mariela Rosales, Eric Van Otterloo, Chad E. Grueter   +5 more
wiley   +1 more source

Early detection of myocardial dysfunction using two-dimensional speckle tracking echocardiography in a young cat with hypertrophic cardiomyopathy

Journal of Feline Medicine and Surgery Open Reports, 2018
Case summary A 5-month-old intact female Scottish Fold cat was presented for cardiac evaluation. Careful auscultation detected a slight systolic murmur (Levine I/VI).
Ryohei Suzuki, Yohei Mochizuki, Hiroki Yoshimatsu, Ayaka Niina, Takahiro Teshima, Hirotaka Matsumoto, Hidekazu Koyama   +6 more
doaj   +1 more source