Results 61 to 70 of about 788,319 (263)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Synthesis of wafer-scale monolayer MoS2 on sapphire: Unlocking the influence of key growth parameters

Nano Research
Large-scale synthesis of high-quality two-dimensional (2D) semiconductors, such as molybdenum disulfide (MoS2), is a prerequisite for their lab-to-fab transition.
Rong Song, Dingyi Shen, Dongyan Liu, Jingyi Liang, Zimei Zhang, Jingmei Tang, Liang Chen, Bo Li, Jia Li, Xidong Duan   +9 more
doaj   +1 more source

Two-dimensional functional materials: from properties to potential applications

International Journal of Smart and Nano Materials, 2020
Two-dimensional (2D) materials have been extensively investigated since the exfoliation of graphene. Due to the excellent and versatile properties, the promising applications in novel nanodevices have been proposed in the last few years.
Yining Wei, Xiao Tang, Jing Shang, Lin Ju, Liangzhi Kou   +4 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Surface cobaltization for boosted kinetics and excellent stability of nickel-rich layered cathodes

National Science Open
The feasibility of LiNi0.6Co0.2Mn0.2O2 as a primary cathode material has decreased due to the fragile cobalt (Co) supply chain and its undesirable effects on structural degradation.
Zhang Qiusheng, Cui Chunyu, Chen Hao, Pan Shuaijun, Zhang Yinghe, Zhu Jian, Lu Bingan   +6 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Synthesis and intrinsic out-of-plane ferroelectricity of 2D Bi2SiO5

Nano Research
Two-dimensional (2D) ferroelectric materials demonstrate promising applications in nanoelectronics owing to their ultrathin thickness and spontaneous polarization.
Di Wang, Yingying Liu, Hongmei Zhang, Dan Li, Hua Zhang, Liqiang Zhang, Shanhao Li, Miaomiao Liu, Zhihui Chen, Xidong Duan   +9 more
doaj   +1 more source

Optical Patterning of Two-Dimensional Materials

Research, 2020
Recent advances in the field of two-dimensional (2D) materials have led to new electronic and photonic devices enabled by their unique properties at atomic thickness. Structuring 2D materials into desired patterns on substrates is often an essential and foremost step for the optimum performance of the functional devices.
Pavana Siddhartha Kollipara, Jingang Li, Yuebing Zheng   +2 more
openaire   +5 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source