Results 71 to 80 of about 24,244,510 (262)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
New Journal of Physics, 2015 The Bose–Hubbard model provides an excellent platform for exploring exotic quantum coherence. Interaction blockade is an important fundamental phenomenon in the two-site Bose–Hubbard system (BHS), which gives a full quantum description for the atomic ...
Xinfang Nie +8 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Dynamic Panel Data Model and Moment Generating Function [PDF]
This paper proposes new sets of moment restrictions for consistently estimating the dynamic panel data model. These sets are derived from solving the moment generating functions of the error term for the dynamic panel data model and have the relevancy ...
Yoshitsugu Kitazawa
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Evaluation of semi-implicit and explicit sedimentation approaches in the two-moment cloud microphysics scheme of ICON [PDF]
Geoscientific Model DevelopmentIn the ICOsahedral Nonhydrostatic (ICON) model, the Seifert-Beheng two-moment microphysics scheme is one approach to simulate clouds with different hydrometeor classes. In this bulk description, sedimentation is modeled by advecting the first two moments
S. Bolt, N. Omanovic
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
USE OF PHYSICAL KINETICS FOR STUDYING OSCILLATIONS PARAMETERS PRODUCTION LINE
East European Journal of Physics, 2015 Presents modern methods of describing the production system. Shows a consistent relationship between the object (micro level) and streaming (macro level) description of the system.
V. D. Khodusov, О. М. Pignasty
doaj