Results 201 to 210 of about 4,821,893 (273)

A Low-Cost 3D Printed Two-Point Discrimination Tool for Evaluation of Sensory Impairment in the Hand. [PDF]

J Hand Microsurg
Chan CM, Efanov JI, Schwiening CJ.
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A Double Shooting Method for Two-Point Boundary Value Problems in Multibody Dynamics

Eichmeir P, Steiner W.
europepmc   +1 more source

Improving quality control procedures for the measurement of total daily energy expenditure using the two-point doubly labeled water method. [PDF]

Rapid Commun Mass Spectrom
Breit MJ, Duncan NM, Dahle JH, Catenacci VA, Creasy SA, Berman ES, Speakman JR, Melanson EL.   +7 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Efficacy of Two-Point Rigid Internal Fixation of Fronto-Zygomatic Suture and Zygomatic Buttress: An Original Research.

J Pharm Bioallied Sci
Chaitanya G, Sushma B, Dubey S, Chaturvedi M, Gupta S, Shah SJ, Anand R.   +6 more
europepmc   +1 more source

Comparisons of Inverse Dynamics Formulations in a Spatial Redundantly Actuated Parallel Mechanism Constrained by Two Point Contact Higher Kinematic Pairs. [PDF]

Biomimetics (Basel)
Cheng C, Yuan X, Li Y, Liu J.
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Mid-term results of intra-articular calcaneal fractures treated with minimally invasive two-point distractor : Single center study with 6-year follow-up. [PDF]

Wien Klin Wochenschr
Stark M, Popp D, Schmoelz L, Doering K, Stark K, Nia A.   +5 more
europepmc   +1 more source