Results 71 to 80 of about 233,629 (274)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
On a Many-Sided Matching Problem with Mixed Preferences [PDF]
Operations Research and DecisionsMotivated by recent results on lexicographic and cyclic preferences, we present new sufficient conditions for the existence of stable matching in many-sided matching problems.
Marcin Anholcer, Maciej Bartkowiak
doaj
Online Assortment Optimization for Two-sided Matching Platforms
SSRN Electronic Journal, 2020 Motivated by online labor markets, we consider the online assortment optimization problem faced by a two-sided matching platform that hosts a set of suppliers waiting to match with a customer. Arriving customers are shown an assortment of suppliers and may choose to issue a match request to one of them.
Ali Aouad, Daniela Saban
openaire +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
IEEE Access, 2020 China is facing an aging society, and more and more disabled elders need Long-Term Care(LTC) from care-givers. On the other hand, care-givers can obtain some income from providing their care services.
Peng Li, Nannan Wang
doaj +1 more source
Uniqueness of Equilibrium in Two-sided Matching [PDF]
This paper analyses a sufficient condition for uniqueness of equilibrium in two-sided matching with non-transferable utility. The condition is easy to interpret, being based on the notion that a person’s characteristics both form the basis of their ...
Simon Clark
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Consistency and Monotonicity in One-Sided Assignment Problems [PDF]
One-sided assignment problems combine important features of two well-known matching models. First, as in roommate problems, any two agents can be matched and second, as in two-sided assignment problems, the payoffs of a matching can be divided between ...
Alexandru Nichifor +1 more
core
Collective Efficiency in Two-Sided Matching [PDF]
, 2006 Gale and Shapley originally proposed the two-sided matching algorithm, Deferred Acceptance Algorithm (DA). This is very brilliant method, but it has a demerit which produces. That is if men propose, it produces stable matching which is the best for men and the worst for women, and vise versa.
Tomoko Fuku +2 more
openaire +1 more source