Results 91 to 100 of about 17,766,923 (318)
Two-Stage Designs for Phase II Clinical Trials
, 2012 [[abstract]]Two-stage designs play an important role in the study of new drugs especially toxicity is the endpoint of interest. Given $(p_0,p_1,\alpha,\beta)$, there exists a set $$S=\{(r_1,n_1,r_2,n_2)|r_1 \leq n_1,r_2 \leq n_2,n_1\in\mathds{N},(r_1,r_2,
蔡重豊, Tsai, Chung-Li
core
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
, 2003 Wet on wet landscape of two white buildings with red roofs. Blue, brown, green, grey and red foreground and grey sky.Tiff file: 2567x3493 pixels, 25.7 Mb; Display: jpeg, 569x800 pixels ...
Father Edward Catich
core
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
, 2003 Wet on wet landscape of two white buildings with red roofs. Black, brown, grey and yellow foreground and blue sky.Tiff file: 2500x3400 pixels, 24.3 Mb; Display: jpeg, 561x740 pixels ...
Father Edward Catich
core
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Management of infected total knee arthroplasty
Acta Orthopaedica et Traumatologica Turcica, 2021 The outcome of primary total knee arthroplasty (TKA) has improved because of a better understanding of biomechanics and techniques. However while there has been a gradual improvement of the results, there were still some problems.
Nadir Sener +2 more
doaj
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source