Results 101 to 110 of about 22,682,382 (285)

A Novel Two-Stage Gas-Excitation Sampling and Sample Delivery Device: Simulation and Experiments

Machines
Asteroids are remnants of primordial material from the early stages of solar system formation, approximately 4.6 billion years ago, and they preserve invaluable records of the processes underlying planetary evolution.
Xu Yang, Dewei Tang, Qiquan Quan, Zongquan Deng   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Quality sampling using coiled tubing drilling in deep mineral exploration

, 2012
The sampling time, the costs and its quality are the three factors that determine the best method of drilling in mineral exploration. The two principal methods of reverse circulation (RC) and diamond core drilling are often used in combination by mine ...
Rasouli, Vamegh, Mokaramian, A., Cavanough, G.   +2 more
core  

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Two-Stage Designs for Phase II Clinical Trials

, 2012
[[abstract]]Two-stage designs play an important role in the study of new drugs especially toxicity is the endpoint of interest. Given $(p_0,p_1,\alpha,\beta)$, there exists a set $$S=\{(r_1,n_1,r_2,n_2)|r_1 \leq n_1,r_2 \leq n_2,n_1\in\mathds{N},(r_1,r_2,
蔡重豊, Tsai, Chung-Li
core  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Balanced two-stage equal probability sampling

, 2022
For two-stage sampling, equal probability sampling method (epsem) by πps-SRS is commonly used in practice. It also provides practical means for controlling cost and fieldwork allocation.
Ali, Shoaib
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

On the implementation of stratified two-stage simple random sampling without replacement, with possible collapsed strata

MethodsX
Two-stage stratified sampling is a complex design that involves nested sampling units and stratification. This complexity increases when the strata have too few sampled units for variance estimation, necessitating the use of collapsed strata, where ...
Philippe Aubry
doaj   +1 more source