Results 111 to 120 of about 22,682,382 (285)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
PLoS ONEImplementing population-based surveys in resource-constrained settings presents logistical challenges when detailed population enumeration is unavailable.
Eva Lorenz +21 more
doaj +2 more sources
IEEE AccessThe increase of Credit Card (CC) fraud in recent years requires the development of fraud detection systems that are both efficient and robust. This paper explored the utilization of machine learning models, with a particular emphasis on ensemble methods,
Ibrahim Almubark
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
MathematicsThis article presents a new set of estimators designed to estimate the finite population variance of a study variable in two-phase sampling. These estimators utilize the information about extreme values and ranks of an auxiliary variable. Through a first-
Umer Daraz +3 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Two-stage sample robust optimization
, 2019 We investigate a simple approximation scheme, based on overlapping linear decision rules, for solving data-driven two-stage distributionally robust optimization problems with the type-$\infty$ Wasserstein ambiguity set. Our main result establishes that this approximation scheme is asymptotically optimal for two-stage stochastic linear optimization ...
Bertsimas, Dimitris +2 more
openaire +2 more sources
On the sample sizes of one-stage and two-stage sampling procedures under heteroscedasticity
, 2011 碩士在檢定母體平均數是否相等的變異數分析方法中，其基本假設是模型誤差項為獨立的常態分布、和有相等變異數。當變異數未知且不相等時，Bishop and Dudewicz (1978) 導出二階段抽樣程序方法，而 Chen (2001) 提出一階段抽樣程序方法，分別用來檢定是否有相同的母體平均數。本文首先討論一階段與二階段抽樣程序在同樣的總樣本數下，比較不同的起始樣本n0 的表現。此外在模型誤差項為不同分布時，討論兩種抽樣程序的型一誤差與檢定力表現。One of the assumptions of ...
蔡泳思; Tsai, Yung-Szu
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source