Results 41 to 50 of about 138,073 (227)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
On the fourth power mean of one special two-term exponential sums
AIMS Mathematics, 2023 <abstract><p>The main purpose of this paper is using the elementary methods and the number of the solutions of some congruence equations to study the calculating problem of the fourth power mean of one special two-term exponential sums, and give an exact calculating formula for it.</p></abstract>
Wenpeng Zhang, Yuanyuan Meng
openaire +2 more sources
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
On the hybrid power mean of two kind different trigonometric sums
Open Mathematics, 2019 The main purpose of this paper is using the analytic method, the properties of trigonometric sums and Gauss sums to study the computational problem of one kind hybrid power mean involving two different trigonometric sums, and give an interesting ...
Zhuoyu Chen, Wenpeng Zhang
doaj +1 more source
Exponential Sums Related to Maass Forms [PDF]
, 2015 We estimate short exponential sums weighted by the Fourier coefficients of a Maass form. This requires working out a certain transformation formula for non-linear exponential sums, which is of independent interest.
Jääsaari, Jesse, Vesalainen, Esa V.
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Computing Dirichlet character sums to a power-full modulus
, 2014 The Postnikov character formula is used to express large portions of a Dirichlet character sum in terms of quadratic exponential sums. The quadratic sums are then computed using an analytic algorithm previously derived by the author.
Hiary, Ghaith A.
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Short-Interval Averages of Sums of Fourier Coefficients of Cusp Forms
, 2016 Let $f$ be a weight $k$ holomorphic cusp form of level one, and let $S_f(n)$ denote the sum of the first $n$ Fourier coefficients of $f$. In analogy with Dirichlet's divisor problem, it is conjectured that $S_f(X) \ll X^{\frac{k-1}{2} + \frac{1}{4 ...
Hulse, Thomas A. +3 more
core +1 more source