Results 71 to 80 of about 31,513,563 (328)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Intrinsic two-way shape memory effect in a Ni-Mn-Sn metamagnetic shape memory microwire

Journal of Materials Science & Technology, 2020
Abstract An intrinsic two-way shape memory effect with a fully recoverable strain of 1.0 % was achieved in an as-prepared Ni50Mn37.5Sn12.5 metamagnetic shape memory microwire fabricated by Taylor-Ulitovsky method. This two-way shape memory effect is mainly owing to the internal stress caused by the retained martensite in austenite matrix, as revealed
Zhen Chen, Daoyong Cong, Yin Zhang, Xiaoming Sun, Runguang Li, Shaohui Li, Zhi Yang, Chao Song, Yuxian Cao, Yang Ren, Yandong Wang   +10 more
openaire   +2 more sources

Tailored One-Way and Two-Way Shape Memory Capabilities of Poly(epsilon-Caprolactone)-Based Systems for Biomedical Applications

, 2013
This paper investigates the shape memory capabilities of semicrystalline networks, focusing the attention on poly(epsilon-caprolactone) (PCL) systems, a class of materials that allows to satisfy important requirements for their applications as biomedical
BODINI, Ileana, VETTURI, David, Stefano Pandini, Luca Dassa, BORBONI, Alberto, PADERNI, KATIA, MESSORI, Massimo, Chiellini, Federica, PILATI, Francesco, Maurizio Toselli, PANDINI, Stefano, Massimo Messori, Theonis Riccò, Alberto Borboni, Katia Paderni, David Vetturi, Francesco Pilati, Cristina Bartoli, Toselli, Maurizio, Bartoli, Cristina, Danilo Cambiaghi, Ileana Bodini, Riccò, Theonis, RICCO', Theonis, Federica Chiellini, Cambiaghi, Danilo   +25 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Construction of a Morphing Wing Rib Actuated by a NiTi Wire

Journal of Aerospace Technology and Management, 2015
The main goal of this paper is to analyze if it is feasible to employ a trained shape memory alloy wire as a linear actuator to modify the camber of a morphing wing rib.
Thais Campos de Almeida, Osmar de Sousa Santos, Jorge Otubo   +2 more
doaj  

On modeling shape memory polymers as elastic two-phase composite materials [PDF]

, 2012
A model has been proposed recently, which describes the experimentally observed mechanical behavior of some shape memory polymers. It considers a purely thermoelastic behavior, without strain rate effects, and assumes essentially that the polymer can be ...
GILORMINI, Pierre, DIANI, Julie, Pierre Gilormini, Julie Diani   +3 more
core   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source