Results 51 to 60 of about 4,151 (244)

Design of a Morphing Skin with Shape Memory Alloy Based on Equivalent Thermal Stress Approach

Micromachines, 2022
Shape memory alloy (SMA) is one of the potential driving devices for morphing aircraft due to its advantages of pseudoelasticity, superelasticity, and shape memory effect.
Wei Zhang, Yueyin Ma, Xinyu Gao, Wanhua Chen, Xutao Nie   +4 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Two-way Shape Memory Effect of NiTi under Compressive Loading Cycles

, 2011
In this study, the two-way shape memory effect (TWSME) of a Ni-54.5 at.% Ti alloy was investigated experimentally to develop a NiTi linear actuator. The two-way shape memory effect was induced through a compressive shape memory cycle composed of four ...
Yoo, Young Ik, Lee, Jung Ju
core   +1 more source

Role of Nickel Content in One-Way and Two-Way Shape Recovery in Binary Ti-Ni Alloys

Metals, 2021
The shape recovery characteristics of titanium nickelide with an Ni content of 50.0 at % and 50.7 at % were studied in a wide range of structures obtained as a result of cold drawing with an accumulated true strain of e = 0.52 and subsequent annealing in
Elena P. Ryklina, Kristina A. Polyakova, Sergey D. Prokoshkin   +2 more
doaj   +1 more source

Intrinsic two-way shape memory effect in a Ni-Mn-Sn metamagnetic shape memory microwire

Journal of Materials Science & Technology, 2020
Abstract An intrinsic two-way shape memory effect with a fully recoverable strain of 1.0 % was achieved in an as-prepared Ni50Mn37.5Sn12.5 metamagnetic shape memory microwire fabricated by Taylor-Ulitovsky method. This two-way shape memory effect is mainly owing to the internal stress caused by the retained martensite in austenite matrix, as revealed
Zhen Chen, Daoyong Cong, Yin Zhang, Xiaoming Sun, Runguang Li, Shaohui Li, Zhi Yang, Chao Song, Yuxian Cao, Yang Ren, Yandong Wang   +10 more
openaire   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Two-way shape memory effect generation in Ni50.3Ti32.2Hf17.5 polycrystals

, 2020
In the present study, the effect of stress-induced martensite ageing on the two-way shape memory effect in aged at 773 K for 3 hours Ni5o.3Ti32.2Hf17.5polycrystals was investigated. It was found that stress-induced martensite aging in NiTiHf polycrystals
Тагильцев, Антон Игоревич, Фаткуллин, Илья Дмитриевич   +1 more
core  

A shape memory alloy adaptive tuned vibration absorber: design and implementation

, 2005
In this paper a tuned vibration absorber (TVA) is realized using shape memory alloy (SMA) elements. The elastic modulus of SMA changes with temperature and this effect is exploited to develop a continuously tunable device.A TVA with beam elements is ...
Brennan, M.J., Mace, B.R., Rustighi, E.
core   +1 more source