Results 51 to 60 of about 41,042 (281)

Intratympanic dexamethasone microcrystals/lidocaine‐loaded PLGA non‐spherical microparticles for local drug delivery to the inner ear

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Optimized lidocaine‐loaded PLGA non‐spherical particles (LPNMs) and dexamethasone microcrystals (DEX MCs) were prepared. They were then mixed in sodium hyaluronate solution to obtain a co‐delivery system, administrated in guinea pigs to evaluate the pharmacokinetics and biocompatibility of the system.
Dongcheng Wang   +7 more
wiley   +1 more source

Cutting‐Edge Advancements in Physical Stimulation for Spiral Ganglion Neuron Protection and Regeneration

open access: yesAdvanced NanoBiomed Research, EarlyView.
Physical stimulation strategies have emerged as a therapeutic avenue for the regeneration of spiral ganglion neurons. This review explores diverse physical stimulation modalities—including topographical modulation, electrical stimulation, and photostimulation—each operating through distinct mechanisms to regulate SGN biological behavior. By elucidating
Yuhan Bai   +7 more
wiley   +1 more source

Systemic corticosteroids for acute otitis media in children [PDF]

open access: yes, 2018
Background: Acute otitis media (AOM) is a common acute infection in children. Pain is its most prominent and distressing symptom. Antibiotics are commonly prescribed for AOM, although they have only a modest effect in reducing pain at two to three days.
Beller, Elaine M   +6 more
core   +1 more source

A Novel, Contactless, Portable “Spot-Check” Device Accurately Measures Respiratory Rate [PDF]

open access: yes, 2020
Respiratory rate (RR) is an important vital sign used in the assessment of acutely ill patients. It is also used as to predict serious deterioration in a patient's clinical condition.
Burke, Derek   +9 more
core   +2 more sources

Early synapsids neurosensory diversity revealed by CT and synchrotron scanning

open access: yesThe Anatomical Record, EarlyView.
Abstract Non‐mammaliaform synapsids (NMS) represent the closest relatives of today's mammals among the early amniotes. Exploring their brain and nervous system is key to understanding how mammals evolved. Here, using CT and Synchrotron scanning, we document for the first time three extreme cases of neurosensory and behavioral adaptations that probe ...
J. Benoit   +6 more
wiley   +1 more source

Graft thickness assessment for surgery of retraction pocket of the middle ear based on finiteele ment analysis of eigenfrequencies of the eardrum oscillating system

open access: yesЖурнал Белорусского государственного университета: Математика, информатика, 2018
The aim of this study is to formulate recommendations for surgery of retraction pocket of the tympanic membrane and improving of hearing. Finite-element analysis of the eigenfrequencies of the oscillatory systems for normal middle ear, middle ear with ...
Gennadi I. Mikhasev   +5 more
doaj  

Use of porcine small intestinal submucosa for pediatric endoscopic tympanic membrane repair

open access: yesWorld Journal of Otorhinolaryngology-Head and Neck Surgery, 2017
Tympanic membrane perforationsoccur frequently in children, and can result in hearing loss, otorrhea, pain, and cholesteatoma. Due to the narrower ear canal in children, a postauricular incision is often needed to access the tympanic membrane for ...
Razan A. Basonbul, Michael S. Cohen
doaj   +1 more source

Identification of quasi-optimal regions in the design space using surrogate modeling [PDF]

open access: yes, 2012
The use of Surrogate Based Optimization (SBO) is widely spread in engineering design to find optimal performance characteristics of expensive simulations (forward analysis: from input to optimal output). However, often the practitioner knows a priori the
Aernouts, Jef   +4 more
core   +2 more sources

Ontogeny of the malleus in Mesocricetus auratus (Mammalia, Rodentia): Systematic and functional implications for the muroid middle ear

open access: yesThe Anatomical Record, EarlyView.
Abstract The three mammalian auditory ossicles enhance sound transmission from the tympanic membrane to the inner ear. The anterior anchoring of the malleus is one of the key characters for functional classification of the auditory ossicles. Previous studies revealed a medial outgrowth of the mallear anterior process, the processus internus ...
Franziska Fritzsche   +2 more
wiley   +1 more source

Ultrastructural alterations of the tympanic membrane in retraction pockets from patients with chronic otitis media

open access: yesPolish Journal of Pathology, 2021
Chronic otitis media with a retraction pocket is one of the forms of chronic otitis media that predisposes to cholesteatoma. The aim of our study was to determine the extent and type of changes in the tympanic membrane fragments which were surgically ...
Dmitry Tretiakow   +2 more
doaj   +1 more source

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