Results 91 to 100 of about 32,520 (234)

Unraveling the molecular basis of subunit specificity in P pilus assembly by mass spectrometry [PDF]

, 2008
P pili are multisubunit fibers essential for the attachment of uropathogenic Escherichia coli to the kidney. These fibers are formed by the noncovalent assembly of six different homologous subunit types in an array that is strictly defined in terms of ...
A. E. Ashcroft, Benesch, Choudhury, D. Verger, Dodson, E. Paci, G. Waksman, Gong, H. Remaut, Jacob-Dubuisson, Jacob-Dubuisson, Jones, R. J. Rose, Remaut, Remaut, Roberts, Rose, S. E. Radford, Sauer, Sauer, Sauer, Saulino, Soto, Stathopoulos, T. Daviter, Thanassi, Thanassi, Verger, Zavialov   +28 more
core   +2 more sources

Molecular Basis for the Enterocyte Tropism Exhibited bySalmonella typhimurium Type 1 Fimbriae [PDF]

Journal of Biological Chemistry, 1999
Salmonella typhimurium exhibits a distinct tropism for mouse enterocytes that is linked to their expression of type 1 fimbriae. The distinct binding traits of Salmonella type 1 fimbriae is also reflected in their binding to selected mannosylated proteins and in their ability to promote secondary bacterial aggregation on enterocyte surfaces.
K, Thankavel, A H, Shah, M S, Cohen, T, Ikeda, R G, Lorenz, R, Curtiss, S N, Abraham   +6 more
openaire   +2 more sources

Chemical dehydration‐induced ultrafast clearing method for human tissues

VIEW, EarlyView.
Three‐dimensional (3D) histology of human tissue through clearing has been hampered by the lengthy and intricate procedure. Here, a rapid and straightforward clearing protocol termed single‐step dehydration solvent‐based clearing (SSD) is proposed via a chemical dehydration strategy.
Yi Dai, Jianyi Xu, Jie Hao, Zhang Liu, Chengze Lan, Guanghua Xu, Xizhi Meng, Yating Deng, Peng Wan, Kunxing Liu, Yingtao Yao, Fang Zhao, Peng Fei, Xiu Nie, Gang Lv, Dan Zhu, Tingting Yu   +16 more
wiley   +1 more source

The structure of the PapD-PapGII pilin complex reveals an open and flexible P5 pocket [PDF]

, 2012
P pili are hairlike polymeric structures that mediate binding of uropathogenic Escherichia coli to the surface of the kidney via the PapG adhesin at their tips.
Baga M, Bann JG, Barnhart MM, Dodson KW, Dodson KW, Doublie S, Gong M, Griebling TL, Henderson NS, Hess B, Holmgren A, Hooton TM, Hultgren SJ, Hung DL, Hung DL, Hung DL, Jacob-Dubuisson F, Jones CH, Justice SS, Kabsch W, Knight SD, Kuehn MJ, Kuehn MJ, Leslie A, Martinez JJ, Munera D, Nishiyama M, Painter J, Pellecchia M, Phan G, Remaut H, Remaut H, Roberts JA, Roberts JA, Rose RJ, Sauer FG, Sauer FG, Sauer FG, Saulino ET, Saulino ET, Sheldrick GM, Slonim LN, Striker R, Stromberg N, Verger D, Verger D, Volkan E, Wright KJ, Zavialov AV   +48 more
core   +2 more sources

Tau‐targeting active immunotherapy slows progression and reduces pathology in mouse models of tauopathy

Brain Pathology, EarlyView.
The efficacy of the novel anti‐tau active immunotherapy, p5555kb, was tested using two mouse models of tau pathology. p5555kb inoculation increased the survival rate and reduced tau pathology in tau‐overexpressing P301L mice and decreased tau seeding in the brains of C57BL/6 mice injected with human‐purified Alzheimer's disease tau.
Christopher M. Brown, Jeanne K. Brooks, Louise Kelly, Madeline M. Vroom, Matthew Longo, Jean‐Cosme Dodart, Roxana Carare, Justin D. Boyd   +7 more
wiley   +1 more source

Analysis of Spleen-Induced Fimbria Production in Recombinant Attenuated Salmonella enterica Serovar Typhimurium Vaccine Strains

mBio, 2017
Salmonella enterica serovar Typhimurium genome encodes 13 fimbrial operons. Most of the fimbriae encoded by these operons are not produced under laboratory conditions but are likely to be synthesized in vivo.
Paweł Łaniewski, Chang-Ho Baek, Kenneth L. Roland, Roy Curtiss   +3 more
doaj   +1 more source

Uropathogenic Escherichia coli P and Type 1 fimbriae act in synergy in a living host to facilitate renal colonization leading to nephron obstruction. [PDF]

PLoS Pathogens, 2011
The progression of a natural bacterial infection is a dynamic process influenced by the physiological characteristics of the target organ. Recent developments in live animal imaging allow for the study of the dynamic microbe-host interplay in real-time ...
Keira Melican, Ruben M Sandoval, Abdul Kader, Lina Josefsson, George A Tanner, Bruce A Molitoris, Agneta Richter-Dahlfors   +6 more
doaj   +1 more source

Sialic acid and N-acetylglucosamine Regulate type 1 Fimbriae Synthesis

Microbiology Spectrum, 2015
ABSTRACT Type 1 fimbriae of E. coli , a chaperon-usher bacterial adhesin, are synthesized by the majority of strains of the bacterium. Although frequently produced by commensal strains, the adhesin is nevertheless a virulence factor in Extraintestinal Pathogenic E. coli (ExPEC). The
openaire   +2 more sources

Body Condition as a Shared Response to Environment in a Commercially Important Demersal Fish Assemblage

Fish and Fisheries, EarlyView.
ABSTRACT Measures of an organism's weight at a given length are often considered reliable indicators of energy reserves or ‘condition’, which can be related to fecundity and risk of mortality. Understanding the impact of environmental change on fish condition may therefore inform sustainable management of human activities in marine ecosystems.
Philina A. English, Sean C. Anderson, Robyn E. Forrest   +2 more
wiley   +1 more source

Porphyromonas gingivalis fimbriae

Journal of Oral Microbiology, 2013
Marginal periodontitis is not a homogeneous disease but is rather influenced by an intricate set of host susceptibility differences as well as diversities in virulence among the harbored organisms. It is likely that clonal heterogeneity of subpopulations
Morten Enersen, Kazuhiko Nakano, Atsuo Amano   +2 more
doaj   +1 more source