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Type 1 Diabetes Genetics Consortium.
J Clin Endocrinol MetabOnengut-Gumuscu S +9 more
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The Lancet, 2006
Type 1 diabetes accounts for only about 5-10% of all cases of diabetes; however, its incidence continues to increase worldwide and it has serious short-term and long-term implications. The disorder has a strong genetic component, inherited mainly through the HLA complex, but the factors that trigger onset of clinical disease remain largely unknown ...
Margaret Grey, Andrea Urban
openaire +6 more sources
Type 1 diabetes accounts for only about 5-10% of all cases of diabetes; however, its incidence continues to increase worldwide and it has serious short-term and long-term implications. The disorder has a strong genetic component, inherited mainly through the HLA complex, but the factors that trigger onset of clinical disease remain largely unknown ...
Margaret Grey, Andrea Urban
openaire +6 more sources
Annals of Internal Medicine, 2022
Type 1 diabetes mellitus (T1DM) is an endocrine disorder in which pancreatic β cells stop producing insulin, typically due to autoimmune destruction. This results in hyperglycemia and ketosis; thus, insulin replacement is vital to management.
Fatima Z. Syed
semanticscholar +1 more source
Type 1 diabetes mellitus (T1DM) is an endocrine disorder in which pancreatic β cells stop producing insulin, typically due to autoimmune destruction. This results in hyperglycemia and ketosis; thus, insulin replacement is vital to management.
Fatima Z. Syed
semanticscholar +1 more source
Immunotherapy for type 1 diabetes
Journal of Endocrinological Investigation, 2017Although many approaches have been tested to overcome the insulin dependence caused by the pancreatic β-cells destruction observed in individuals affected by type 1 diabetes (T1D), medical research has largely failed to halt the onset or to reverse T1D.In this work, the state of the art of immunotherapy will be examined, and the most important ...
Davide Frumento +6 more
openaire +3 more sources