Results 321 to 330 of about 2,796,719 (361)

Type 1 Diabetes Risk Variants Reduce Beta Cell Function. [PDF]

Genes (Basel)
Ratajczak W, Jones AG, Atkinson SD, Kelly C.   +3 more
europepmc   +1 more source

Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU‐EMRE Assembly

Advanced Science, EarlyView.
Berberine, a safe and FDA‐approved drug, is identified as a novel mitochondrial calcium uniporter (MCU) inhibitor. By disrupting MCU‐EMRE interaction, Berberine prevents mitochondrial calcium overload and protects against ischemia/reperfusion injury, offering a promising therapeutic strategy for diseases linked to mitochondrial calcium dysregulation ...
Haixin Zhao, Siqi Chen, Nian Cao, Wenjun Wu, Guangqin Liu, Jun Gao, Jiayi Chen, Ting Li, Dingyi Lu, Lingmin Zeng, Haizhen Zhu, Weina Zhang, Qing Xia, Teng Li, Tao Zhou, Xue‐Min Zhang, Ai‐Ling Li, Xin Pan   +17 more
wiley   +1 more source

Comparison Between Antenatal and Postnatal Colostrum From Women With and Without Type 1 Diabetes. [PDF]

J Hum Lact
Goldberg A, Pettersson H, Ekéus C, Ursing C, Wiberg-Itzel E, Tingström J.   +5 more
europepmc   +1 more source

Screening and Identification of Novel DNA Aptamer for Targeted Delivery to Injured Podocytes in Glomerular Diseases

Advanced Science, EarlyView.
This study develops RLS‐2, a high‐affinity aptamer that specifically targets injured podocytes, making it a promising candidate for targeted drug delivery. In vitro, RLS‐2 shows stability, specificity, efficient siRNA delivery via AsiCs, and uptake by podocytes.
Chao Zhou, Zhaofeng Luo, Zheng Zhang, Qing Ye, Dongjie Wang, Hanyan Meng, Jiayu Zhang, Shifan Zhu, Lidan Hu, Jianhua Mao   +9 more
wiley   +1 more source

Evaluating cloudcare, a population health management system, in persons with type 1 diabetes: an observational study. [PDF]

BMC Endocr Disord
van Beers CAJ, Last S, Dekker P, Birnie E, Riegman N, van der Pluijm F, Fransman C, Veeze HJ, Aanstoot HJ.   +8 more
europepmc   +1 more source

The Super Enhancer‐Driven Long Noncoding RNA PRKCQ‐AS1 Promotes Neuroblastoma Tumorigenesis by Interacting With MSI2 Protein and Is Targetable by Small Molecule Compounds

Advanced Science, EarlyView.
PRKCQ‐AS1 is overexpressed due to transcriptional super‐enhancers. PRKCQ‐AS1 RNA forms a complex with MSI2 protein to induce BMX mRNA stabilization and overexpression, ERK protein phosphorylation and neuroblastoma cell proliferation. Compound NSC617570 blocks PRKCQ‐AS1 binding to MSI2, leading to BMX mRNA disassociation from MSI2 protein, BMX reduction,
Sujanna Mondal, Pei Y. Liu, Janith Seneviratne, Antoine De Weck, Pooja Venkat, Chelsea Mayoh, Jing Wu, Jesper Maag, Jingwei Chen, Matthew Wong, Nenad Bartonicek, Poh Khoo, Lei Jin, Louise E. Ludlow, David S. Ziegler, Toby Trahair, Pieter Mestdagh, Belamy B. Cheung, Jinyan Li, Marcel E. Dinger, Ian Street, Xu D. Zhang, Glenn M. Marshall, Tao Liu   +23 more
wiley   +1 more source

The XCL1/XCR1 axis is upregulated in type 1 diabetes and aggravates its pathogenesis. [PDF]

JCI Insight
Tondello C, Bender C, Golden GJ, Puppe D, Blickberndt E, Bayer M, Buchmann GK, Pfeilschifter J, Bachmann M, Hintermann E, Brandes RP, Betts MR, Kroczek RA, Christen U.   +13 more
europepmc   +1 more source

Depletion of Hepatic SREBP2 Protects Against Hypercholesterolemia and Atherosclerosis through the ANGPTL3‐LPL Axis

Advanced Science, EarlyView.
This study reveals a novel crosstalk between hepatic SREBP2‐mediated cholesterol biosynthesis pathway and peripheral lipoprotein lipase‐mediated lipolysis pathway in the regulation of systemic lipid metabolism. Notably, the lipid‐lowering effects of SREBP2 inhibition are independent of a functional LDL receptor, highlighting the potential of acute ...
Yifan Wang, Jia You Sarafina Choe, Yu Shi, Thi Tun Thi, Xiaoyun Cao, Yang Hu, Kai Yan Cheng, Hui Li, Yang Ji, Yan Liu, Matthew Ackers‐Johnson, Roger S.Y. Foo, Yujia Shen, Haojie Yu   +13 more
wiley   +1 more source

Food Consumption and Risk of Islet Autoimmunity and Type 1 Diabetes in Children at Increased Genetic Susceptibility for Type 1 Diabetes. [PDF]

J Nutr
Virtanen SM, Peltonen EJ, Hakola L, Niinistö S, Takkinen HM, Ahonen S, Åkerlund M, Uusitalo U, Mattila M, Salo TE, Ilonen J, Toppari J, Veijola R, Knip M, Nevalainen J.   +14 more
europepmc   +1 more source