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Insulin Resistance in Type 1 Diabetes: Pathophysiological, Clinical, and Therapeutic Relevance.
Endocr RevApostolopoulou M +3 more
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The Lancet, 2006
Type 1 diabetes accounts for only about 5-10% of all cases of diabetes; however, its incidence continues to increase worldwide and it has serious short-term and long-term implications. The disorder has a strong genetic component, inherited mainly through the HLA complex, but the factors that trigger onset of clinical disease remain largely unknown ...
Margaret Grey, Andrea Urban
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Type 1 diabetes accounts for only about 5-10% of all cases of diabetes; however, its incidence continues to increase worldwide and it has serious short-term and long-term implications. The disorder has a strong genetic component, inherited mainly through the HLA complex, but the factors that trigger onset of clinical disease remain largely unknown ...
Margaret Grey, Andrea Urban
openaire +6 more sources
Immunotherapy for type 1 diabetes
Journal of Endocrinological Investigation, 2017Although many approaches have been tested to overcome the insulin dependence caused by the pancreatic β-cells destruction observed in individuals affected by type 1 diabetes (T1D), medical research has largely failed to halt the onset or to reverse T1D.In this work, the state of the art of immunotherapy will be examined, and the most important ...
Davide Frumento +6 more
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Diabetic nephropathy in type 1 diabetes
Minerva Medica, 2018Diabetic nephropathy (DN) also named diabetic kidney disease (DN) is one of the leading causes of mortality in people with diabetes. The aim of this review is to update the medical literature, the theories behind its early natural history, the pathways of its pathogenesis, its diagnosis and treatment.
Nikolaos Marketos +5 more
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Pediatric Diabetes, 2016
Environmental factors play an important role in the pathogenesis of type 1 diabetes and can determine if a genetically susceptible individual develops the disease. Increasing evidence suggest that among other exogenous agents certain virus infections can contribute to the beta-cell damaging process.
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Environmental factors play an important role in the pathogenesis of type 1 diabetes and can determine if a genetically susceptible individual develops the disease. Increasing evidence suggest that among other exogenous agents certain virus infections can contribute to the beta-cell damaging process.
openaire +3 more sources
Evolving type 1 diabetes in distinguishing between type 1 and type 2 diabetes
BMJ, 2020Distinguishing between newly diagnosed type 1 or type 2 diabetes can be challenging.1 As a nation, we are becoming more obese, thus increasing predisposition to type 2 diabetes, and we are more often recognising type 1 diabetes in older adults.23 This can blur the lines between type 1 and type 2 diabetes. All relevant factors should be considered when
Neil E. Hill, Nick Oliver
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, 2012 Type 1 diabetes is increasing in prevalence in different parts of the world. Type 1 diabetes is unique among autoimmune diseases in not having a clear female predisposition. Gender differences are present for the pattern of complications in patients with type 1 diabetes, especially with regard to cardiovascular complications.
Simon Coppack +3 more
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2011
Type 1 Diabetes (2011) has been completely updated for the 2nd edition. The background is introduced with a review of aetiology, classification, and presentation in young people and adults. The major longitudinal studies (DCCT/EDIC, Pittsburgh, and FinnDiane) are discussed and their importance in defining the long-term outcomes of Type 1 diabetes in ...
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Type 1 Diabetes (2011) has been completely updated for the 2nd edition. The background is introduced with a review of aetiology, classification, and presentation in young people and adults. The major longitudinal studies (DCCT/EDIC, Pittsburgh, and FinnDiane) are discussed and their importance in defining the long-term outcomes of Type 1 diabetes in ...
openaire +2 more sources
Nature Immunology, 2001
Type 1 diabetes is preventable in animal models and predictable in humans. The increase in our knowledge of basic immunology has allowed the initiation of large-scale clinical efforts to prevent diabetes.
George S. Eisenbarth +1 more
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Type 1 diabetes is preventable in animal models and predictable in humans. The increase in our knowledge of basic immunology has allowed the initiation of large-scale clinical efforts to prevent diabetes.
George S. Eisenbarth +1 more
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, 2009 Type 1 diabetes is a life long metabolic disorder that is characterized by absolute insulin deficiency resulting in hyperglycemia and lipolysis. Type 1 diabetes accounts for 5–10% of the total diabetes population, the majority of the other patients has type 2 diabetes. Insulin deficiency originates with autoimmune mediated β-cell destruction.
Edith ter Braak, Aline M.E. Stades
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