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Introduction to Diabetes and Type 1 Diabetes
2016The World Health Organization (WHO) classification of diabetes has been the subject of subtle iterations over the years, with their most recent classification published back in 1985. At that time an expert committee on the diagnosis and classification of diabetes mellitus identified two main types of diabetes: type 1 diabetes (T1D) and type 2 diabetes (
Singh, Prachi +7 more
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Nature Reviews Drug Discovery, 2010
Type 1 diabetes (T1D), also termed juvenile-onset or insulin-dependent diabetes, is an autoimmune disease and a metabolic disorder characterized by T-cell-mediated destruction of pancreatic β cells, resulting in insulin deficiency and hyperglycaemia. In 2007, it was reported that 437,500 children were affected by T1D worldwide1.
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Type 1 diabetes (T1D), also termed juvenile-onset or insulin-dependent diabetes, is an autoimmune disease and a metabolic disorder characterized by T-cell-mediated destruction of pancreatic β cells, resulting in insulin deficiency and hyperglycaemia. In 2007, it was reported that 437,500 children were affected by T1D worldwide1.
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2017
This chapter discusses the epidemiology, genetics, and pathophysiology of type 1 diabetes including insulinitis and β-cell destruction in the Eisenbarth model of pathogenesis. Complications of type 1 diabetes and pregnancy are reviewed, and diagnosis and management are discussed.
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This chapter discusses the epidemiology, genetics, and pathophysiology of type 1 diabetes including insulinitis and β-cell destruction in the Eisenbarth model of pathogenesis. Complications of type 1 diabetes and pregnancy are reviewed, and diagnosis and management are discussed.
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