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2011
Type 1 Diabetes (2011) has been completely updated for the 2nd edition. The background is introduced with a review of aetiology, classification, and presentation in young people and adults. The major longitudinal studies (DCCT/EDIC, Pittsburgh, and FinnDiane) are discussed and their importance in defining the long-term outcomes of Type 1 diabetes in ...
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Type 1 Diabetes (2011) has been completely updated for the 2nd edition. The background is introduced with a review of aetiology, classification, and presentation in young people and adults. The major longitudinal studies (DCCT/EDIC, Pittsburgh, and FinnDiane) are discussed and their importance in defining the long-term outcomes of Type 1 diabetes in ...
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, 2009 Type 1 diabetes is a life long metabolic disorder that is characterized by absolute insulin deficiency resulting in hyperglycemia and lipolysis. Type 1 diabetes accounts for 5–10% of the total diabetes population, the majority of the other patients has type 2 diabetes. Insulin deficiency originates with autoimmune mediated β-cell destruction.
Edith ter Braak, Aline M.E. Stades
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Nature Immunology, 2001
Type 1 diabetes is preventable in animal models and predictable in humans. The increase in our knowledge of basic immunology has allowed the initiation of large-scale clinical efforts to prevent diabetes.
George S. Eisenbarth +1 more
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Type 1 diabetes is preventable in animal models and predictable in humans. The increase in our knowledge of basic immunology has allowed the initiation of large-scale clinical efforts to prevent diabetes.
George S. Eisenbarth +1 more
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Introduction to Diabetes and Type 1 Diabetes
2016The World Health Organization (WHO) classification of diabetes has been the subject of subtle iterations over the years, with their most recent classification published back in 1985. At that time an expert committee on the diagnosis and classification of diabetes mellitus identified two main types of diabetes: type 1 diabetes (T1D) and type 2 diabetes (
Singh, Prachi +7 more
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2020
Diabetes mellitus (DM) is the most common endocrine and metabolic disease caused by absolute or insufficient insulin secretion. Under the context of an aging population worldwide, the number of diabetic patients is increasing year by year. Most patients with diabetes have multiple complications that severely threaten their survival and living quality ...
Xiya Lu, Cuimei Zhao
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Diabetes mellitus (DM) is the most common endocrine and metabolic disease caused by absolute or insufficient insulin secretion. Under the context of an aging population worldwide, the number of diabetic patients is increasing year by year. Most patients with diabetes have multiple complications that severely threaten their survival and living quality ...
Xiya Lu, Cuimei Zhao
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Hormone Research, 1996
Prediction of type 1 diabetes is largely based on islet cell antibodies, but may be improved by combined analysis with other markers. We conducted a screening of first-degree relatives of type 1 diabetic patients in Germany using islet cell antibodies (ICA, indirect immunofluorescence on human pancreas) and insulin autoantibodies (IAA, radioimmunoassay)
D. Seidel, A.-G. Ziegler
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Prediction of type 1 diabetes is largely based on islet cell antibodies, but may be improved by combined analysis with other markers. We conducted a screening of first-degree relatives of type 1 diabetic patients in Germany using islet cell antibodies (ICA, indirect immunofluorescence on human pancreas) and insulin autoantibodies (IAA, radioimmunoassay)
D. Seidel, A.-G. Ziegler
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Nature Reviews Drug Discovery, 2010
Type 1 diabetes (T1D), also termed juvenile-onset or insulin-dependent diabetes, is an autoimmune disease and a metabolic disorder characterized by T-cell-mediated destruction of pancreatic β cells, resulting in insulin deficiency and hyperglycaemia. In 2007, it was reported that 437,500 children were affected by T1D worldwide1.
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Type 1 diabetes (T1D), also termed juvenile-onset or insulin-dependent diabetes, is an autoimmune disease and a metabolic disorder characterized by T-cell-mediated destruction of pancreatic β cells, resulting in insulin deficiency and hyperglycaemia. In 2007, it was reported that 437,500 children were affected by T1D worldwide1.
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2017
This chapter discusses the epidemiology, genetics, and pathophysiology of type 1 diabetes including insulinitis and β-cell destruction in the Eisenbarth model of pathogenesis. Complications of type 1 diabetes and pregnancy are reviewed, and diagnosis and management are discussed.
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This chapter discusses the epidemiology, genetics, and pathophysiology of type 1 diabetes including insulinitis and β-cell destruction in the Eisenbarth model of pathogenesis. Complications of type 1 diabetes and pregnancy are reviewed, and diagnosis and management are discussed.
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