Results 91 to 100 of about 1,164,150 (315)

Lipoic Acid‐Intervened Decellularized Stem Cell Spheroid‐Based Injectable Granular Gel for Diabetic Tissue Regeneration

Advanced Science, EarlyView.
ABSTRACT Advancements in tissue engineering have revolutionized therapeutic paradigms for diabetic tissue defects; however, the lack of applicable scaffold containing various bioactive substance aggregates remained a critical bottleneck hindering satisfactory repair effect.
Tao Wang, Haowei Fang, Lili Qi, Song Myoungseop, Aawrish Khan, Lunli Gong, Guangdong Zhou, Kunxi Zhang, Haiyan Cui   +8 more
wiley   +1 more source

Role of cytokines in the pathogenesis of type 1 diabetes

, 1996
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.T lymphocytes and macrophages appear to play an important role in mediating ß-cell damage and causing Type 1 diabetes.
Hussain, Munther Jaffar
core  

Sex-specific-differences in cardiovascular risk in type-1-diabetes : a cross sectional study [PDF]

, 2013
Background: Little is known about the impact of sex-specific differences in the management of type 1 diabetes (T1DM). Thus, we evaluated the influence of gender on risk factors, complications, clinical care and adherence in patients with T1DM.
Kautzky, Alexander, Saukel, Johannes (Department of Pharmacognosy, Faculty of Life Sciences, University of Vienna), Stich, Kathrin (Department of Pharmacology and Toxicology, Faculty of Life Sciences, University of Vienna), Alexander Kautzky, Kautzky, Alexander (Gender Medicine Unit, Department of Internal Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna), Hintersteiner, Juliane (Department of Pharmacology and Toxicology, Faculty of Life Sciences, University of Vienna), Kautzky-Willer, Alexandra (Gender Medicine Unit, Department of Internal Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna), Johannes Saukel, Kautzky-Willer, Alexandra, Stich, Kathrin, Lemmens-Gruber, Rosa, Lemmens-Gruber, Rosa (Department of Pharmacology and Toxicology, Faculty of Life Sciences, University of Vienna), Saukel, Johannes, Majid Kamyar, Johnson, Julienne, Juliane Hintersteiner, Hinstersteiner, Juliane, Kamyar, Majid (Department of Pharmacology and Toxicology, Faculty of Life Sciences, University of Vienna), Alexandra Kautzky-Willer, Kathrin Stich, Johnson, Julienne (Strathclyde Institute of Pharmacy and Biomedical Sciences, Strathclyde University), Kamyar, Majid Reza, Julienne Johnson, Rosa Lemmens-Gruber   +23 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Type 1 diabetes mellitus: retrospect and prospect

Bulletin of the National Research Centre
Background Type 1 diabetes (T1D) is an autoimmune disease leading to destruction of insulin-producing pancreatic beta cells. Both genetic and environmental factors contribute to pathogenesis. The incidence of T1D is increasing worldwide, with significant
Tamer A. Addissouky, Majeed M. A. Ali, Ibrahim El Tantawy El Sayed, Yuliang Wang   +3 more
doaj   +1 more source

A gyermekkori 1-es típusú diabétesz genetikai és humorális immunológiai hátterének vizsgálata = Genetic and humoral immunologic determinants of childhood-onset type 1 diabetes

, 2007
Az OTKA pályázat munkatervében kitűzött célok megvalósultak. A program az elmúlt három év alatt országos diabetes genetikai projektté nőtte ki magát (HUN-T1D-GENES program; www.diabet.hu/ diabetesgenetics).
Hermann, Róbert, Soltész, Gyula
core  

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

Advanced Science, EarlyView.
It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou, Xi Zhang, Sihan Chen, Mengchi Yu, Yilan Hu, Chi Gan, Xianghu Meng, Long Li, Ninghong Song   +8 more
wiley   +1 more source

Intestinal Source Control of Lipid Metabolism by Enzyme‐Probiotic Encapsulated, Spatiotemporal Crosslinked, and Small Intestine‐Adhesive Hydrogel Microspheres

Advanced Science, EarlyView.
A thiol‐modified alginate hydrogel microsphere‐encapsulated enzyme‐probiotic biohybrid (AKK‐COD) system has been developed to address the spatiotemporal delivery and colonization challenges of small intestine‐targeted probiotic for lipid metabolism regulation. The system exerts sequential functions of intragastric protection, small intestinal adhesion,
Xiaolin Wu, Weiwen Liang, Siqi He, Guangyuan Chen, Hui Zhou, Xinglong Wang, Yifei Li, Dingcai Wu, Bingna Zheng, Ruoxu Dou, Rongkang Huang   +10 more
wiley   +1 more source

Vitamin D supplementation in patients with diabetes mellitus type 2 on different therapeutic regimens : a one-year prospective study [PDF]

, 2013
Background Little or no research has determined the effect of vitamin D3 supplementation in conjunction with pharmacological and non-pharmacological approaches in the diabetes mellitus type 2 (DMT2) patients. The objective of this study was to determine
Majed S Alokail, Al-Othman, Abdulaziz, Osama Moharram, Yousef Al-Saleh, Shaun B Sabico, Chrousos, George P., Kumar, Sudhesh, Sabico, Shaun, Abdulaziz Al-Othman, Nasser M Al-Daghri, Sudhesh Kumar, George P Chrousos, Alokail, Majed S., Al-Daghri, Nasser M., Al-Saleh, Yousef, Moharram, Osama, Alkharfy, Khalid M., Khalid M Alkharfy   +17 more
core   +1 more source

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source