Results 141 to 150 of about 36,609,695 (340)

Multifunctional Manganese Oxide Nanocomposite Hydrogel With Synergistic Reactive Oxygen Species‐Scavenging, Oxygen‐Generating, Immunomodulatory, and Photothermal Antimicrobial Activities for Enhanced Diabetic Wound Healing

Advanced Science, EarlyView.
CFP/PC@MnO2 hydrogel integrates ROS scavenging, oxygen delivery, oxidative stress reduction, immunomodulation, and photothermal antibacterial properties. The incorporation of PC@MnO2 NPs endows the hydrogel with multiple functional advantages tailored to the pathological microenvironment of diabetic wounds, including efficient ROS clearance, mitigation
Zhi Xu, Xiaodong Luo, Jingxian Wu, Chaoyang Huang, Zhuoying Yang, Yixiang HePeng, Bosong Zhou, Xiang Li, Ruiyuan Liu, Xu Wu   +9 more
wiley   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Neglected-Noncompliant Type 1 Diabetes Mellitus with Complications

Jurnal Kesehatan Andalas, 2012
AbstrakDiabetes mellitus (DM) tipe 1 merupakan kelainan sistemik akibat terjadinya gangguan metabolisme glukosayang ditandai oleh hiperglikemia kronis.
Afdal ., Eka Agustia Rini
doaj  

Problems of applying inflammatory markers to diagnostics of anemia of chronic disease in patients with type 1 and type 2 diabetes

Медицинская иммунология
The purpose of the study was to evaluate the severity of changes in the values of markers-candidates for the differential diagnosis of anemia of chronic diseases in patients with type 1 and type 2 diabetes mellitus.
N. N. Musina, T. S. Prokhorenko, T. V. Saprina, A. P. Zima   +3 more
doaj   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen.

New England Journal of Medicine, 2000
A. M. James Shapiro, J. Lakey, E. Ryan, G. Korbutt, E. Toth, Garth L. Warnock, Norman M. Kneteman, R. Rajotte   +7 more
semanticscholar   +1 more source

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

Fulminant type 1 diabetes: A distinct subtype of type 1 diabetes mellitus

Journal of the Formosan Medical Association, 2013
Jiao Fu, Bing-Yin Shi
doaj   +1 more source

PHARMACOLOGICAL NEUROPROTECTION OF TYPE 1 DIABETES MELLITUS

Ukrainian Scientific Medical Youth Journal, 2016
Type 1 diabetes mellitus (DM) - one of the most common diseases of modern endocrinology. The growing number of sick children, emergence of chronic diseases and high percentage of disability determine the severity of the problem. Diabetic neuropathy (DN),
O. Fitsner, M. Khaitovych
doaj  

Association of RPS26 gene polymorphism with different types of diabetes in Chinese individuals

Journal of Diabetes Investigation
Aims/Introduction Different types of diabetes show distinct genetic characteristics, but the specific genetic susceptibility factors remain unclear. Our study aimed to explore the associations between the ribosomal protein S26 (RPS26) gene rs1131017 ...
Rong Song, Lingxiang Xie, Jin Ding, Yan Chen, Hailan Zou, Haipeng Pang, Yiman Peng, Ying Xia, Zhiguo Xie, Xia Li, Yang Xiao, Zhiguang Zhou, Jingyi Hu   +12 more
doaj   +1 more source