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The Lancet, 2022
Type 2 diabetes accounts for nearly 90% of the approximately 537 million cases of diabetes worldwide. The number affected is increasing rapidly with alarming trends in children and young adults (up to age 40 years). Early detection and proactive management are crucial for prevention and mitigation of microvascular and macrovascular complications and ...
Ehtasham, Ahmad +4 more
openaire +2 more sources
Type 2 diabetes accounts for nearly 90% of the approximately 537 million cases of diabetes worldwide. The number affected is increasing rapidly with alarming trends in children and young adults (up to age 40 years). Early detection and proactive management are crucial for prevention and mitigation of microvascular and macrovascular complications and ...
Ehtasham, Ahmad +4 more
openaire +2 more sources
The Lancet, 2005
Type 2 diabetes in adolescents is reported to be increasing in prevalence. Its complications may occur dramatically earlier in patients who develop it during adolescence compared with the traditional patients who develop diabetes in middle age. It may be difficult to differentiate types of diabetes at the time of diagnosis; in this article, some ...
+6 more sources
Type 2 diabetes in adolescents is reported to be increasing in prevalence. Its complications may occur dramatically earlier in patients who develop it during adolescence compared with the traditional patients who develop diabetes in middle age. It may be difficult to differentiate types of diabetes at the time of diagnosis; in this article, some ...
+6 more sources
The Lancet, 2017
415 million people live with diabetes worldwide, and an estimated 193 million people have undiagnosed diabetes. Type 2 diabetes accounts for more than 90% of patients with diabetes and leads to microvascular and macrovascular complications that cause profound psychological and physical distress to both patients and carers and put a huge burden on ...
Sudesna, Chatterjee +2 more
openaire +3 more sources
415 million people live with diabetes worldwide, and an estimated 193 million people have undiagnosed diabetes. Type 2 diabetes accounts for more than 90% of patients with diabetes and leads to microvascular and macrovascular complications that cause profound psychological and physical distress to both patients and carers and put a huge burden on ...
Sudesna, Chatterjee +2 more
openaire +3 more sources
Minerva Pediatrics, 2022
Type 2 diabetes (T2D) in adolescents has become an increasing health concern throughout the world and its prevention and screening should be implemented in pediatric care. As clinical features at presentation, in some cases can be similar to type 1 diabetes and family history can be in favor of a monogenic form of diabetes, it is pivotal for physicians
FORNARI, Elena +6 more
openaire +4 more sources
Type 2 diabetes (T2D) in adolescents has become an increasing health concern throughout the world and its prevention and screening should be implemented in pediatric care. As clinical features at presentation, in some cases can be similar to type 1 diabetes and family history can be in favor of a monogenic form of diabetes, it is pivotal for physicians
FORNARI, Elena +6 more
openaire +4 more sources
Nature Reviews Disease Primers, 2015
Type 2 diabetes mellitus (T2DM) is an expanding global health problem, closely linked to the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular complications (including retinopathy, nephropathy and neuropathy) and macrovascular complications (such as cardiovascular comorbidities), owing to hyperglycaemia and individual ...
DeFronzo, Ralph A +12 more
openaire +5 more sources
Type 2 diabetes mellitus (T2DM) is an expanding global health problem, closely linked to the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular complications (including retinopathy, nephropathy and neuropathy) and macrovascular complications (such as cardiovascular comorbidities), owing to hyperglycaemia and individual ...
DeFronzo, Ralph A +12 more
openaire +5 more sources
Annals of Internal Medicine, 2010
Type 2 diabetes is a prevalent illness that causes major vascular, renal, and neurologic complications. Prevention and treatment of diabetes and its complications are of paramount importance. Many new treatments have emerged over the past 5-10 years. Recent evidence shows that newer treatments may substantially reduce risk for cardiac and renal disease,
openaire +4 more sources
Type 2 diabetes is a prevalent illness that causes major vascular, renal, and neurologic complications. Prevention and treatment of diabetes and its complications are of paramount importance. Many new treatments have emerged over the past 5-10 years. Recent evidence shows that newer treatments may substantially reduce risk for cardiac and renal disease,
openaire +4 more sources
Primary Care: Clinics in Office Practice, 2008
The rapid and often relentless progression of type 2 diabetes suggests that high-risk patients should be provided with an equally aggressive strategy to protect their remaining beta-cell function and endogenous insulin secretion. Management of patients with prediabetes should incorporate both lifestyle and pharmacologic intervention.
Jeff, Unger, Cynthia, Moriarty
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The rapid and often relentless progression of type 2 diabetes suggests that high-risk patients should be provided with an equally aggressive strategy to protect their remaining beta-cell function and endogenous insulin secretion. Management of patients with prediabetes should incorporate both lifestyle and pharmacologic intervention.
Jeff, Unger, Cynthia, Moriarty
openaire +2 more sources
2011
The evolving concept of how nutrient excess and inflammation modulate metabolism provides new opportunities for strategies to correct the detrimental health consequences of obesity. In this review, we focus on the complex interplay among lipid overload, immune response, proinflammatory pathways and organelle dysfunction through which excess adiposity ...
Christina, Schwanstecher +1 more
openaire +2 more sources
The evolving concept of how nutrient excess and inflammation modulate metabolism provides new opportunities for strategies to correct the detrimental health consequences of obesity. In this review, we focus on the complex interplay among lipid overload, immune response, proinflammatory pathways and organelle dysfunction through which excess adiposity ...
Christina, Schwanstecher +1 more
openaire +2 more sources