Results 81 to 90 of about 119,720,646 (296)

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

The onset of acute type A aortic dissection following recovery of type B intramural haematoma: a case report

BMC Cardiovascular Disorders, 2020
Background Aortic intramural hematoma is a life-threatening condition reported with increasing frequency. It can be classified into Stanford type A or B depending on whether the ascending or descending aorta are involved, respectively. However, the onset
Kai Zhang, Song-Bo Dong, Xu-Dong Pan, Li-Zhong Sun   +3 more
doaj   +1 more source

Strategies for subacute/chronic type B aortic dissection: the Investigation Of Stent Grafts in Patients with type B Aortic Dissection (INSTEAD) trial 1-year outcome

, 2010
Endovascular stent grafting represents a novel concept for type B aortic dissection both in the acute and subacute/chronic setting, with an unknown effect on ...
Kleinfeldt, Tilo, Rehders, Tim C, Fattori, Rossella, Guenther Kundt, Ibrahim Akin, Louis Labrousse, Rousseau, Hervé, Ince, Hüseyin, Stephan Kische, Tilo Kleinfeldt, Burkhart Zipfel, Martin Czerny, Scheinert, Dierk, Hervé Rousseau, Nienaber, Christoph A, Czerny, Martin, Christoph A. Nienaber, Zipfel, Burkhart, Holger Eggebrecht, Tim C. Rehders, Hüseyin Ince, Rossella Fattori, Labrousse, Louis, Eggebrecht, Holger, Kundt, Guenther, Dierk Scheinert, Kische, Stephan, Akin, Ibrahim   +27 more
core   +1 more source

Checkpoint‐Directed Glycoengineering Reprograms the Vascular Lumen for Siglec‐Mediated Immune Regulation

Advanced Science, EarlyView.
Checkpoint‐directed glycoengineering installs sialylated ligands on the donor vascular lumen during ex vivo preservation, creating a localized Siglec‐7/9‐engaging interface. The engineered glycocalyx suppresses immune‐cell activation, complement deposition, and microvascular injury in arterial and kidney allografts while preserving endothelial ...
Md Mohosin Rana, Javairia F. Rahim, Aaron P. Bernstein, Peyman Malek Mohammadi Nouri, Lyann Sim, Winnie Enns, Jenice M. Dumlao, Haiming D. Luo, Irina Chafeeva, Hong‐Ming Chen, Aizhou Wang, Jiao‐Jing Wang, Edward N. Schmidt, Zheng Jenny Zhang, Marcelo Cypel, Christopher Nguan, Matthew S. Macauley, Stephen G. Withers, Jonathan C. Choy, Jayachandran N. Kizhakkedathu   +19 more
wiley   +1 more source

Intra-aortic balloon pump can be used after acute type A aortic dissection repair

Journal of Cardiothoracic Surgery
Objectives We analyzed our data to evaluate the safety and feasibility of intraoperative extracorporeal membrane oxygenation and intra-aortic balloon pump use in acute type A aortic dissection repair.
Akiko Tanaka, Yuki Ikeno, Harleen K. Sandhu, Charles C. Miller III, Hazim J. Safi, Anthony L. Estrera   +5 more
doaj   +1 more source

Importance of Multiple-window Assessment for the Diagnosis of Ascending Aortic Dissection Using Point-of-care Ultrasound: Report of Three Cases

Clinical Practice and Cases in Emergency Medicine, 2019
Acute ascending aortic dissection has a high mortality rate and requires rapid diagnosis and treatment. Point-of-care ultrasound (POCUS) can aid in the diagnosis.
Virginia Zarama, María C. Arango-Granados, Luis A. Bustamante Cristancho   +2 more
doaj   +1 more source

Does aortic crossclamping during the cooling phase affect the early clinical outcome of acute type a aortic dissection?

, 2008
The purpose of this study is to evaluate the effects of crossclamping the ascending aorta in acute type A aortic dissection during the cooling phase for deep hypothermic arrest on early clinical ...
Eckstein, Friedrich S., Krähenbühl, Eva S, Carrel, Thierry P, Krähenbühl, Eva S., Stalder, Mario, Schmidli, Jürg, Englberger, Lars, Aydin, Naz Bige, Carrel, Thierry P., Immer, Franz F, Eckstein, Friedrich S, Immer, Franz F., Lütolf, Magdalena, Englberger L, Eckstein FS, Immer FF, Carrel, Thierry, Immer, Franz Ferdinand, Carrel TP, Aydin NB, Schmidli J, Stalder M, Roost, Eva, Krähenbühl ES, Lütolf M, Eckstein, Friedrich Stefan   +25 more
core   +1 more source

Targeting Nupr1‐Mediated p53 Mitochondrial Sequestration Alleviates Aortic Dissection by Restoring the Gadd45b‐Dependent Survival Program

Advanced Science, EarlyView.
This study identifies Nupr1 as a crucial stress‐responsive orchestrator driving AD. Under severe stress, Nupr1 massively accumulates within mitochondria to sequester p53, triggering apoptosis and concurrently repressing the Gadd45b‐mediated survival program.
Xi Yang, Ke‐Yuan Chen, Yue Tian, Zong‐Sheng Jiang, Jian Lei, Xing‐Hui Zhuang, Jiang‐Bin Wu, Le‐Le Tang, Hao‐Yu Li, Xiao‐Hui Chen, Yue Wang, Yu‐Mei Li, Zhi‐Huang Qiu, Zi‐Wen Cai, Liang‐Wan Chen   +14 more
wiley   +1 more source

Thermally Drawn Bioelectric Catheters: Enabling Proprioceptive Endovascular Navigation

Advanced Intelligent Systems, EarlyView.
This work introduces a novel bioelectric navigation system eliminates the need for harmful fluoroscopy during endovascular surgeries. A bespoke 16‐electrode catheter is fabricated using rapid thermal drawing and laser micro‐machining. Paired with a real‐time tracking algorithm fusing vascular geometry detection and distance estimation, this technology ...
Alex Ranne, Heiko Maier, Jinshi Zhao, Songli Moey, Ayhan Aktas, Manik Chana, Burak Temelkuran, Nassir Navab, Ferdinando Rodriguez y Baena   +8 more
wiley   +1 more source