Results 191 to 200 of about 18,426,765 (306)

When NCX switches sides: Experimental and computational insights into Ca2+ regulation in the heart

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Due to its presence inside the dyadic cleft, Na+/Ca2+ exchanger (NCX) builds a functional unit together with L‐type calcium channels and ryanodine receptors in the dyadic cleft. NCX acts bidirectionally (forward and reverse mode) dependent on extracellular calcium ([Ca2+]o) and sodium ([Na+]o) concentrations and the membrane ...
Wilhelm Neubert   +6 more
wiley   +1 more source

Percutaneous Aortic Fenestration for Symptomatic Type B Aortic Dissection [PDF]

open access: yesSeminars in Interventional Radiology, 2017
Johnathan, Fergus, Brian, Funaki
openaire   +2 more sources

Visualization analysis of research hotspots and trends in Type B Aortic Dissection based on bibliometrics. [PDF]

open access: yesJ Cardiothorac Surg
Li Y   +9 more
europepmc   +1 more source

Vascular smooth muscle cell mechanotransduction: Pathways, phenotypes and emerging technologies

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Vascular smooth muscle cells are exposed to mechanical stimuli from the blood flow and the extracellular matrix. The cells sense the signals from cyclic stretch, shear stress, hydrostatic pressure and matrix stiffness through specialized mechanosensors, such as mechanosensitive ion channels or cell surface receptors including ...
Nivethitha Kota Lakshminaraasimulu   +3 more
wiley   +1 more source

Sedentary ageing remodels the structure–function relationships that underlie calcium signalling at super‐resolution scales in the heart

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Illustration of calcium spark function and ryanodine receptor (RyR) structure within a sedentary model of ageing. Upon sympathetic stimulation from 1 µM isoprenaline a linear response to calcium spark morphology occurred, accompanied by a biphasic progression of RyR remodelling across age.
Miriam E. Hurley   +3 more
wiley   +1 more source

Beat‐to‐beat variability of ventricular repolarization reveals sex‐specific instability and proarrhythmic risk

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato   +3 more
wiley   +1 more source

Visceral Ischemia and Gastric Perforation in Acute Type B Aortic Dissection. [PDF]

open access: yesKorean Circ J
Liu Y   +7 more
europepmc   +1 more source

Myostatin‐dependent detrusor remodelling mediates contractility impairment in diabetic rats’ bladder – a maximal elastance analysis

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend In the muscular layer of long‐standing diabetic bladders increased myostatin expression promotes tissue remodelling by reducing the muscle‐to‐collagen ratio, ultimately diminishing bladder contractility. Maximal elastance – defined as the slope of the end‐emission pressure–volume relationship (EPR), derived from the regression ...
Cheng‐Yuan Lai   +6 more
wiley   +1 more source

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