Results 71 to 80 of about 18,426,765 (306)

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Type B aortic dissection: new perspectives [PDF]

Journal of Visualized Surgery, 2018
Stanford type B aortic dissection is one of the aortic catastrophes with a high mortality and morbidity that needs immediate or delayed treatment, either surgically or endovascularly. This comprehensive review article addresses the current status of open, endovascular and hybrid treatment options for type B aortic dissections with the focus on new ...
openaire   +2 more sources

Morphologic predictors of aortic dilatation in type B aortic dissection [PDF]

Journal of Vascular Surgery, 2013
Conservative management of acute type B aortic dissection (ABAD) is often associated with aortic dilatation during follow-up increasing the risk of aortic rupture. The goal of this study was to investigate whether morphologic characteristics of the dissection can predict aortic growth.All conservatively managed ABAD patients from four referral centers ...
J. L. Tolenaar, J. W. Van Keulen, F. H. W. Jonker, J. A. Van Herwaarden, H. J. Verhagen, F. L. Moll, B. E. Muhs, S. Trimarchi   +7 more
openaire   +3 more sources

Ascending thoracic aorta dimension and outcomes in acute type B dissection (from the International Registry of Acute Aortic Dissection [IRAD])

, 2011
It is not well known if the size of the ascending thoracic aorta at presentation predicts features of presentation, management, and outcomes in patients with acute type B aortic dissection.
J. B. Froehlich, Froehlich, James B, V. S. Ramanath, Ramanath, Vijay S, C. A. Nienaber, James B. Froehlich, Santi Trimarchi, O'Gara, Patrick T, Booher, Anna M, Harris, Kevin M, Reed E. Pyeritz, International Registry of Acute Aortic Dissection (IRAD) Investi,, Anna M. Booher, J. V. Cooper, Sundt, Thoralf M, Januzzi, James L, Eric M. Isselbacher, Nienaber, Christoph A, T. M. Sundt III, Christoph A. Nienaber, James L. Januzzi, Thoralf M. Sundt, Cooper, Jeanna V, S. Demertzis, Demertzis, Stefanos, Trimarchi, Santi, Jeanna V. Cooper, Vijay S. Ramanath, K. M. Harris, Kim A. Eagle, R. E. Pyeritz, K. A. Eagle, Patrick T. O'Gara, Pyeritz, Reed E, J. L. Januzzi, Eagle, Kim A, E. M. Isselbacher, P. T. O'Gara, S. Trimarchi, Kevin M. Harris, A. M. Booher, Stefanos Demertzis, Isselbacher, Eric M   +42 more
core   +1 more source

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

Treatment for Stanford type B aortic dissection with insufficient anchoring region using castor integrated branched aortic stent graft

Frontiers in Cardiovascular Medicine
BackgroundTo investigate the clinical efficacy of Castor integrated branched aortic stent graft for the treatment of Stanford type B aortic dissection with insufficient anchoring area.MethodsRetrospective analysis of clinical data of 26 patients with ...
Weiqing Chen, Dabing Liu, Tao Chen, Jian Liu, Yi Guo, Bo Ye   +5 more
doaj   +1 more source

Predictors of aortic growth in uncomplicated type B aortic dissection [PDF]

Journal of Vascular Surgery, 2014
Patients with uncomplicated acute type B aortic dissection (ABAD) generally can be treated with conservative medical management. However, these patients may develop aortic enlargement during follow-up, with the risk for rupture, which necessitates intervention.
van Bogerijen, Guido H.W., Tolenaar, Jip L., Rampoldi, Vincenzo, Moll, Frans L., van Herwaarden, Joost A., Jonker, Frederik H.W., Eagle, Kim A., Trimarchi, Santi   +7 more
openaire   +2 more sources

Acute type B aortic dissection: does aortic arch involvement affect management and outcomes? Insights from the International Registry of Acute Aortic Dissection (IRAD).

, 2007
BACKGROUND: Stanford Type B acute aortic dissection (TB-AAD) spares the ascending aorta and is optimally managed with medical therapy in the absence of complications.
Isselbacher EM, Oh JK, Eagle KA, Fattori R, FATTORI, ROSSELLA, Llovet A, Nienaber CA, Evangelista A, International Registry of Acute Aortic Dissection, Januzzi JL, Beckman J, Cooper JV, Tsai TT, Smith DE, Trimarchi S, Pape L, Froehlich JB, Bossone E   +17 more
core   +1 more source

Increased Disarray of Extracellular Matrix Collagen‐I Fiber Network and Compromised Biomechanics in Aortae From Marfan‐Syndrome Mice Assessed Through Combined Opto‐Biomechatronics

Advanced Science, EarlyView.
Combined structure‐function assessment in aortic rings from Marfan mice using MechaMorph Opto‐Biomechatronics technology relates increased elasticity (stiffness) and dynamic viscosity and less ordered extracellular matrix 3D‐structure (collagen) as potential causes for impaired Windkessel function and compromised haemodynamics in Marfan's syndrome ...
Dominik Schneidereit, Anika Nagel, Vanessa I. T. Zwaans, Laureen Schurr, Jonas Ahr, Michael Haug, Anna Piluso, Alexandra Sporkova, Matthias Karck, Andreas H. Wagner, Oliver Friedrich   +10 more
wiley   +1 more source

Retrograde Type A Aortic Dissection after Thoracic Endovascular Aortic Repair for Type B Dissection

The Heart Surgery Forum, 2020
Background: A 64-year-old woman presented with dilatation of the distal aortic arch secondary to chronic type B aortic dissection. Case Report: The patient underwent fenestrated thoracic endovascular aortic repair (TEVAR) for closure of the entry site, and reconstruction of the left subclavian artery with a covered stent. On the 40th postoperative day,
Masato, Hayakawa, Takaaki, Nagano, Isao, Nishijima, Kento, Shinzato, Ryo, Ikemura, Kazufumi, Miyagi, Kiyoshi, Iha, Shigenobu, Senaha, Mitsuyoshi, Shimoji, Mitsuru, Akasaki   +9 more
openaire   +3 more sources