Results 141 to 150 of about 15,878,608 (386)

The apo LETM1 F‐EF‐hand adopts a closed conformation that underlies a multi‐modal sensory role in mitochondria

open access: yesFEBS Letters, EarlyView.
We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin   +2 more
wiley   +1 more source

Saddleback Research Project Collection Tabulation [PDF]

open access: yes, 1960
This student inventory of insects found on Saddleback Mountain is part of Dr. Jane Claire Dirks-Edmunds\u27s ecological study of the area. The physical collection of the Dr.
Lovell, Dorwin
core   +1 more source

The Type Organism Approach to Biology Instruction

open access: yesThe American Biology Teacher, 1949
Though for some years the emphasis of biology teaching has been directed away from classification systems and taxonomic aims, still a considerable portion of the biology courses and textbooks is given to the task of broadening the learner's orientation and developing his organization of his knowledge of life forms.
openaire   +2 more sources

Functionally diverse type V CRISPR-Cas systems

open access: yesScience, 2019
Additional, diverse CRISPR systems CRISPR systems have been revolutionizing molecular biology. Mining the metagenomic database, Yan et al. systematically discovered additional subtypes of type V CRISPR-Cas systems.
Winston X. Yan   +11 more
semanticscholar   +1 more source

Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones

open access: yesFEBS Letters, EarlyView.
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley   +1 more source

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

open access: yesFEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra   +7 more
wiley   +1 more source

Teaching Biology Lessons Using Digital Technology: A Contextualized Mixed-Methods Study on Pre-Service Biology Teachers’ Enacted TPACK

open access: yesEducation Sciences
Pre-service biology teachers must apply Technological Pedagogical and Content Knowledge (TPACK) acquired at university in real classroom situations to utilize the instructional potential of digital technologies for teaching biology.
Alexander Aumann   +2 more
doaj   +1 more source

PENINGKATAN HASIL BELAJAR BIOLOGI SISWA MELALUI PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE GROUP INVESTIGATION

open access: yesJurnal BIOEDUIN, 2018
Investigation group is a type of cooperative learning which stresses on the participation, activeness, and involves students in planning, determining the topic as well as the way to investigate. An investigation group learing type also guides students to
Asrianty Mas’ud
doaj   +1 more source

Non-equilibrium statistical physics, transitory epigenetic landscapes, and cell fate decision dynamics [PDF]

open access: yesarXiv, 2020
Statistical physics provides a useful perspective for the analysis of many complex systems; it allows us to relate microscopic fluctuations to macroscopic observations. Developmental biology, but also cell biology more generally, are examples where apparently robust behaviour emerges from highly complex and stochastic sub-cellular processes.
arxiv  

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

open access: yesFEBS Letters, EarlyView.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause   +2 more
wiley   +1 more source

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