Results 161 to 170 of about 15,878,608 (386)
Simultaneous lineage tracing and cell-type identification using CRISPR/Cas9-induced genetic scars
Nature Biotechnology, 2018 A key goal of developmental biology is to understand how a single cell is transformed into a full-grown organism comprising many different cell types.
B. Spanjaard +6 more
semanticscholar +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Type III Protein Secretion Systems in Bacterial Pathogens of Animals and Plants
Microbiology and Molecular Biology Reviews, 1998 SUMMARY Various gram-negative animal and plant pathogens use a novel, sec-independent protein secretion system as a basic virulence mechanism. It is becoming increasingly clear that these so-called type III secretion systems inject (translocate) proteins
Christoph J. Hueck
semanticscholar +1 more source
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Jurnal BIOEDUIN, 2019 This study aims to determine the drawing based modeling implementation aid eBeam Capture in stimulating the Microscopic Representation of Prospective Biology Teachers in the Digital Era.
Tomi Hidayat +3 more
doaj +1 more source
A twenty-first century statistical physics of life [PDF]
arXivThe molecular biology revolution of the last seventy five years has transformed our view of living systems. Scientific explanations of biological phenomena are now synonymous with the identification of the genes, proteins, and signaling molecules involved.
arxiv
Methods of Information Theory and Algorithmic Complexity for Network Biology [PDF]
arXiv, 2014 We survey and introduce concepts and tools located at the intersection of information theory and network biology. We show that Shannon's information entropy, compressibility and algorithmic complexity quantify different local and global aspects of synthetic and biological data.
arxiv
Biology and treatment of Richter syndrome.
Blood, 2018 Richter syndrome (RS) is the development of an aggressive lymphoma in patients with chronic lymphocytic leukemia (CLL). Two pathologic variants of RS are recognized: namely, the diffuse large B-cell lymphoma (DLBCL) variant and the rare Hodgkin lymphoma (
D. Rossi, V. Spina, G. Gaidano
semanticscholar +1 more source
FEBS Letters, EarlyView.The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet +4 more
wiley +1 more source
The Biological Consequences of the Computational World: Mathematical Reflections on Cancer Biology [PDF]
arXiv, 2017 The role of continua has been clear since antiquity in the mathematical approaches to physics, while discrete manifolds were brought to the limelight mostly by Quantum and Information Theories, in the XX century. We first recall how theorizing and measuring radically change in physics when using discrete vs. continuous mathematical manifolds.
arxiv